MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation
Mesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and in clinical trials for multiple disease states. The differentiation, trophic, and immunomodulatory characteristics of MSCs contribute to their therapeutic effects. Another often overlooked factor related to eff...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2013/732742 |
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| author | Thomas J. Kean Paul Lin Arnold I. Caplan James E. Dennis |
| author_facet | Thomas J. Kean Paul Lin Arnold I. Caplan James E. Dennis |
| author_sort | Thomas J. Kean |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and in clinical trials for multiple disease states. The differentiation, trophic, and immunomodulatory characteristics of MSCs contribute to their therapeutic effects. Another often overlooked factor related to efficacy is the degree of engraftment. When reported, engraftment is generally low and transient in nature. MSC delivery methods should be tailored to the lesion being treated, which may be local or systemic, and customized to the mechanism of action of the MSCs, which can also be local or systemic. Engraftment efficiency is enhanced by using intra-arterial delivery instead of intravenous delivery, thus avoiding the “first-pass” accumulation of MSCs in the lung. Several methodologies to target MSCs to specific organs are being developed. These cell targeting methodologies focus on the modification of cell surface molecules through chemical, genetic, and coating techniques to promote selective adherence to particular organs or tissues. Future improvements in targeting and delivery methodologies to improve engraftment are expected to improve therapeutic results, extend the duration of efficacy, and reduce the effective (MSC) therapeutic dose. |
| format | Article |
| id | doaj-art-5431f2eb612c4865b33be7818ecd8040 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5431f2eb612c4865b33be7818ecd80402025-02-03T06:06:25ZengWileyStem Cells International1687-966X1687-96782013-01-01201310.1155/2013/732742732742MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune ModulationThomas J. Kean0Paul Lin1Arnold I. Caplan2James E. Dennis3Benaroya Research Institute, Seattle, WA 98101, USASkeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USASkeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USABenaroya Research Institute, Seattle, WA 98101, USAMesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and in clinical trials for multiple disease states. The differentiation, trophic, and immunomodulatory characteristics of MSCs contribute to their therapeutic effects. Another often overlooked factor related to efficacy is the degree of engraftment. When reported, engraftment is generally low and transient in nature. MSC delivery methods should be tailored to the lesion being treated, which may be local or systemic, and customized to the mechanism of action of the MSCs, which can also be local or systemic. Engraftment efficiency is enhanced by using intra-arterial delivery instead of intravenous delivery, thus avoiding the “first-pass” accumulation of MSCs in the lung. Several methodologies to target MSCs to specific organs are being developed. These cell targeting methodologies focus on the modification of cell surface molecules through chemical, genetic, and coating techniques to promote selective adherence to particular organs or tissues. Future improvements in targeting and delivery methodologies to improve engraftment are expected to improve therapeutic results, extend the duration of efficacy, and reduce the effective (MSC) therapeutic dose.http://dx.doi.org/10.1155/2013/732742 |
| spellingShingle | Thomas J. Kean Paul Lin Arnold I. Caplan James E. Dennis MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation Stem Cells International |
| title | MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation |
| title_full | MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation |
| title_fullStr | MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation |
| title_full_unstemmed | MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation |
| title_short | MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation |
| title_sort | mscs delivery routes and engraftment cell targeting strategies and immune modulation |
| url | http://dx.doi.org/10.1155/2013/732742 |
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