HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient
Human herpesvirus 8 (HHV-8), also known as Kaposi’s sarcoma-associated herpesvirus, is a DNA oncovirus known for its role in the development of Kaposi’s sarcoma (KS) and several lymphoproliferative disorders (LPDs). HHV-8 promotes lymphoproliferation via the activation of the interleukin-6 receptor...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/4536157 |
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| author | Carlo Guerrero Tania Jain Katalin Kelemen |
| author_facet | Carlo Guerrero Tania Jain Katalin Kelemen |
| author_sort | Carlo Guerrero |
| collection | DOAJ |
| description | Human herpesvirus 8 (HHV-8), also known as Kaposi’s sarcoma-associated herpesvirus, is a DNA oncovirus known for its role in the development of Kaposi’s sarcoma (KS) and several lymphoproliferative disorders (LPDs). HHV-8 promotes lymphoproliferation via the activation of the interleukin-6 receptor signaling pathway, as well as a host of other regulatory mechanisms. The spectrum of HHV-8-associated LPDs is increasing. The World Health Organization has recently updated the classification of HHV-8-associated LPDs by introducing HHV-8-positive germinotropic LPD (GLPD) in addition to the previously recognized entities of HHV-8-positive diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), primary effusion lymphoma (PEL), and HHV-8-positive multicentric Castleman’s disease (MCD). We present here a case of an HIV-positive woman with a history of KS, who later developed three HHV-8-associated LPDs, including HHV-8-positive MCD, PEL, and GLPD. To the best of our knowledge, this is the first reported case of a patient with this combination of individually rare HHV-8-associated LPDs. This case illustrates the spectrum and the sequential development of the different clinical manifestations of HHV-8-associated diseases. Detection of HHV-8 can have clinical significance in the diagnosis and management of certain HHV-8-associated conditions. Recently discovered variants of HHV-8-associated LPDs indicate that this group represents a diverse spectrum of disorders, whose classification may require further refinement beyond the currently recognized entities. |
| format | Article |
| id | doaj-art-54315b98127f4359ade3aed38603549b |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-54315b98127f4359ade3aed38603549b2025-02-03T01:02:30ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/45361574536157HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive PatientCarlo Guerrero0Tania Jain1Katalin Kelemen2Department of Medicine, Houston Methodist Hospital, Houston, TX, USAAdult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ, USAHuman herpesvirus 8 (HHV-8), also known as Kaposi’s sarcoma-associated herpesvirus, is a DNA oncovirus known for its role in the development of Kaposi’s sarcoma (KS) and several lymphoproliferative disorders (LPDs). HHV-8 promotes lymphoproliferation via the activation of the interleukin-6 receptor signaling pathway, as well as a host of other regulatory mechanisms. The spectrum of HHV-8-associated LPDs is increasing. The World Health Organization has recently updated the classification of HHV-8-associated LPDs by introducing HHV-8-positive germinotropic LPD (GLPD) in addition to the previously recognized entities of HHV-8-positive diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), primary effusion lymphoma (PEL), and HHV-8-positive multicentric Castleman’s disease (MCD). We present here a case of an HIV-positive woman with a history of KS, who later developed three HHV-8-associated LPDs, including HHV-8-positive MCD, PEL, and GLPD. To the best of our knowledge, this is the first reported case of a patient with this combination of individually rare HHV-8-associated LPDs. This case illustrates the spectrum and the sequential development of the different clinical manifestations of HHV-8-associated diseases. Detection of HHV-8 can have clinical significance in the diagnosis and management of certain HHV-8-associated conditions. Recently discovered variants of HHV-8-associated LPDs indicate that this group represents a diverse spectrum of disorders, whose classification may require further refinement beyond the currently recognized entities.http://dx.doi.org/10.1155/2019/4536157 |
| spellingShingle | Carlo Guerrero Tania Jain Katalin Kelemen HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient Case Reports in Hematology |
| title | HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient |
| title_full | HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient |
| title_fullStr | HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient |
| title_full_unstemmed | HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient |
| title_short | HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient |
| title_sort | hhv 8 associated lymphoproliferative disorders and pathogenesis in an hiv positive patient |
| url | http://dx.doi.org/10.1155/2019/4536157 |
| work_keys_str_mv | AT carloguerrero hhv8associatedlymphoproliferativedisordersandpathogenesisinanhivpositivepatient AT taniajain hhv8associatedlymphoproliferativedisordersandpathogenesisinanhivpositivepatient AT katalinkelemen hhv8associatedlymphoproliferativedisordersandpathogenesisinanhivpositivepatient |