Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1

Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1

In contrast to natural antibodies that rely mainly on the heavy chain to establish contacts with their cognate antigen, we have developed a bispecific antibody format in which the light chain (LC) drives antigen binding and specificity. To better understand epitope-paratope interactions in this cont...

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Bibliographic Details
Main Authors: Pauline Malinge, Xavier Chauchet, Jérémie Bourguignon, Nicolas Bosson, Sébastien Calloud, Tereza Bautzova, Marie Borlet, Mette Laursen, Vinardas Kelpsas, Nadia Rose, Franck Gueneau, Ulla Ravn, Giovanni Magistrelli, Nicolas Fischer
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Bispecific
light chain
CD47
PD-L1
structure
X-ray crystallography
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2362432
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