Physiological and pathological roles of PGAM5: An update and future trend
Summary: PGAM5, a phosphatase found in mitochondria, is crucial for mitochondrial quality control (MQC) through its regulation on mitochondrial dynamics, biogenesis, and mitophagy. Previous studies have shown its involvement in multiple regulated cell deaths (RCDs), including apoptosis, necroptosis,...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224027664 |
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| author | Weibin He Wenlong He Zhongchan Sun Pengcheng He |
| author_facet | Weibin He Wenlong He Zhongchan Sun Pengcheng He |
| author_sort | Weibin He |
| collection | DOAJ |
| description | Summary: PGAM5, a phosphatase found in mitochondria, is crucial for mitochondrial quality control (MQC) through its regulation on mitochondrial dynamics, biogenesis, and mitophagy. Previous studies have shown its involvement in multiple regulated cell deaths (RCDs), including apoptosis, necroptosis, and pyroptosis. The objective of this review is to enhance our comprehension of the involvement of PGAM5 in MQC and RCDs. Additionally, we summarize some novel roles of PGAM5 in cellular senescence, lipid metabolism, and immune response modulation in recent studies. Finally, we discuss PGAM5’s contribution to the pathological state of cardiovascular, hepatic, neurological, and neoplastic diseases, offering potential perspectives for future research. |
| format | Article |
| id | doaj-art-5410f0cbd97d4e33abc6c5ce64a3b14b |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-5410f0cbd97d4e33abc6c5ce64a3b14b2025-01-24T04:45:34ZengElsevieriScience2589-00422025-02-01282111539Physiological and pathological roles of PGAM5: An update and future trendWeibin He0Wenlong He1Zhongchan Sun2Pengcheng He3Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences) Southern Medical University, Guangzhou 510080, China; Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Guangdong Cardiovascular Institute, Guangzhou 510080, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences) Southern Medical University, Guangzhou 510080, China; Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Guangdong Cardiovascular Institute, Guangzhou 510080, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences) Southern Medical University, Guangzhou 510080, China; Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Guangdong Cardiovascular Institute, Guangzhou 510080, China; Corresponding authorDepartment of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences) Southern Medical University, Guangzhou 510080, China; Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Guangdong Cardiovascular Institute, Guangzhou 510080, China; Department of Cardiology, Heyuan People’s Hospital, Heyuan 517000, China; Corresponding authorSummary: PGAM5, a phosphatase found in mitochondria, is crucial for mitochondrial quality control (MQC) through its regulation on mitochondrial dynamics, biogenesis, and mitophagy. Previous studies have shown its involvement in multiple regulated cell deaths (RCDs), including apoptosis, necroptosis, and pyroptosis. The objective of this review is to enhance our comprehension of the involvement of PGAM5 in MQC and RCDs. Additionally, we summarize some novel roles of PGAM5 in cellular senescence, lipid metabolism, and immune response modulation in recent studies. Finally, we discuss PGAM5’s contribution to the pathological state of cardiovascular, hepatic, neurological, and neoplastic diseases, offering potential perspectives for future research.http://www.sciencedirect.com/science/article/pii/S2589004224027664PathologyBiological sciencesMolecular physiology |
| spellingShingle | Weibin He Wenlong He Zhongchan Sun Pengcheng He Physiological and pathological roles of PGAM5: An update and future trend iScience Pathology Biological sciences Molecular physiology |
| title | Physiological and pathological roles of PGAM5: An update and future trend |
| title_full | Physiological and pathological roles of PGAM5: An update and future trend |
| title_fullStr | Physiological and pathological roles of PGAM5: An update and future trend |
| title_full_unstemmed | Physiological and pathological roles of PGAM5: An update and future trend |
| title_short | Physiological and pathological roles of PGAM5: An update and future trend |
| title_sort | physiological and pathological roles of pgam5 an update and future trend |
| topic | Pathology Biological sciences Molecular physiology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224027664 |
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