The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk
Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or macrophage dysfunction plays a particularly significant role in asthma pathogenesis. Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/7835284 |
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| author | Xueyi Zhu Jie Cui La Yi Jingjing Qin Wuniqiemu Tulake Fangzhou Teng Weifeng Tang Ying Wei Jingcheng Dong |
| author_facet | Xueyi Zhu Jie Cui La Yi Jingjing Qin Wuniqiemu Tulake Fangzhou Teng Weifeng Tang Ying Wei Jingcheng Dong |
| author_sort | Xueyi Zhu |
| collection | DOAJ |
| description | Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or macrophage dysfunction plays a particularly significant role in asthma pathogenesis. Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune cell activation or repression in the immune response. Consequently, the imbalanced immune microenvironment is the major cause of the exacerbation of asthma. Here, we discuss the role of T cells, macrophages, and their interactions in asthma pathogenesis. |
| format | Article |
| id | doaj-art-53f56642a5394641be118a1a2695a10c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-53f56642a5394641be118a1a2695a10c2025-02-03T01:05:02ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/78352847835284The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual CrosstalkXueyi Zhu0Jie Cui1La Yi2Jingjing Qin3Wuniqiemu Tulake4Fangzhou Teng5Weifeng Tang6Ying Wei7Jingcheng Dong8Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, ChinaAsthma is associated with innate and adaptive immunity mediated by immune cells. T cell or macrophage dysfunction plays a particularly significant role in asthma pathogenesis. Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune cell activation or repression in the immune response. Consequently, the imbalanced immune microenvironment is the major cause of the exacerbation of asthma. Here, we discuss the role of T cells, macrophages, and their interactions in asthma pathogenesis.http://dx.doi.org/10.1155/2020/7835284 |
| spellingShingle | Xueyi Zhu Jie Cui La Yi Jingjing Qin Wuniqiemu Tulake Fangzhou Teng Weifeng Tang Ying Wei Jingcheng Dong The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk Mediators of Inflammation |
| title | The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk |
| title_full | The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk |
| title_fullStr | The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk |
| title_full_unstemmed | The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk |
| title_short | The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk |
| title_sort | role of t cells and macrophages in asthma pathogenesis a new perspective on mutual crosstalk |
| url | http://dx.doi.org/10.1155/2020/7835284 |
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