Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells
Spinal cord injury (SCI) is an intractable and worldwide difficult medical challenge with limited treatments. Neural stem/progenitor cell (NS/PC) transplantation derived from fetal tissues or embryonic stem cells (ESCs) has demonstrated therapeutic effects via replacement of lost neurons and severed...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/5653787 |
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| author | Junhao Deng Yiling Zhang Yong Xie Licheng Zhang Peifu Tang |
| author_facet | Junhao Deng Yiling Zhang Yong Xie Licheng Zhang Peifu Tang |
| author_sort | Junhao Deng |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is an intractable and worldwide difficult medical challenge with limited treatments. Neural stem/progenitor cell (NS/PC) transplantation derived from fetal tissues or embryonic stem cells (ESCs) has demonstrated therapeutic effects via replacement of lost neurons and severed axons and creation of permissive microenvironment to promote repair of spinal cord and axon regeneration but causes ethnical concerns and immunological rejections as well. Thus, the implementation of induced pluripotent stem cells (iPSCs), which can be generated from adult somatic cells and differentiated into NS/PCs, provides an effective alternation in the treatment of SCI. However, as researches further deepen, there is accumulating evidence that the use of iPSC-derived NS/PCs shows mounting concerns of safety, especially the tumorigenicity. This review discusses the tumorigenicity of iPSC-derived NS/PCs focusing on the two different routes of tumorigenicity (teratomas and true tumors) and underlying mechanisms behind them, as well as possible solutions to circumvent them. |
| format | Article |
| id | doaj-art-53f3263471034e83b0aef2c943ead617 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-53f3263471034e83b0aef2c943ead6172025-02-03T05:55:19ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/56537875653787Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor CellsJunhao Deng0Yiling Zhang1Yong Xie2Licheng Zhang3Peifu Tang4Department of Orthopaedics, Chinese PLA General Hospital, No. 28 Fuxin Road, Beijing 100853, ChinaDepartment of Orthopaedics, Chinese PLA General Hospital, No. 28 Fuxin Road, Beijing 100853, ChinaDepartment of Orthopaedics, Chinese PLA General Hospital, No. 28 Fuxin Road, Beijing 100853, ChinaDepartment of Orthopaedics, Chinese PLA General Hospital, No. 28 Fuxin Road, Beijing 100853, ChinaDepartment of Orthopaedics, Chinese PLA General Hospital, No. 28 Fuxin Road, Beijing 100853, ChinaSpinal cord injury (SCI) is an intractable and worldwide difficult medical challenge with limited treatments. Neural stem/progenitor cell (NS/PC) transplantation derived from fetal tissues or embryonic stem cells (ESCs) has demonstrated therapeutic effects via replacement of lost neurons and severed axons and creation of permissive microenvironment to promote repair of spinal cord and axon regeneration but causes ethnical concerns and immunological rejections as well. Thus, the implementation of induced pluripotent stem cells (iPSCs), which can be generated from adult somatic cells and differentiated into NS/PCs, provides an effective alternation in the treatment of SCI. However, as researches further deepen, there is accumulating evidence that the use of iPSC-derived NS/PCs shows mounting concerns of safety, especially the tumorigenicity. This review discusses the tumorigenicity of iPSC-derived NS/PCs focusing on the two different routes of tumorigenicity (teratomas and true tumors) and underlying mechanisms behind them, as well as possible solutions to circumvent them.http://dx.doi.org/10.1155/2018/5653787 |
| spellingShingle | Junhao Deng Yiling Zhang Yong Xie Licheng Zhang Peifu Tang Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells Stem Cells International |
| title | Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells |
| title_full | Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells |
| title_fullStr | Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells |
| title_full_unstemmed | Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells |
| title_short | Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells |
| title_sort | cell transplantation for spinal cord injury tumorigenicity of induced pluripotent stem cell derived neural stem progenitor cells |
| url | http://dx.doi.org/10.1155/2018/5653787 |
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