DHX34 deficiency triggers tumor-intrinsic immunity via a dsRNA-mediated type I interferon pathway activation in HCC

DHX34 deficiency triggers tumor-intrinsic immunity via a dsRNA-mediated type I interferon pathway activation in HCC

Tumors often evade immune surveillance by crippling their immunogenicity in the microenvironment. DHX34, an RNA helicase involved in nonsense-mediated mRNA decay pathway, is critical for aberrant RNA degradation. However, the effect of DHX34 in regulating the immunogenicity in hepatocellular carcino...

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Bibliographic Details
Main Authors: Chunli Zhang, Limin Huang, Zeyu Li, Qian Wang, Nanbin Liu, Chongyu Zhang, Xi Liu, Chen Zhang, Gaixia He, Jin Sun, Zongfang Li, Hongwei Tian
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
DHX34
Hepatocellular carcinoma
dsRNA
Immune evasion
Type I interferon
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000788
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