PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis

PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis

PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The m...

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Bibliographic Details
Main Authors: Naoko Okumura, Hitomi Yoshida, Yasuko Kitagishi, Mutsumi Murakami, Yuri Nishimura, Satoru Matsuda
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Advances in Hematology
Online Access:http://dx.doi.org/10.1155/2012/843085
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