PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The m...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/843085 |
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| _version_ | 1832565854451007488 |
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| author | Naoko Okumura Hitomi Yoshida Yasuko Kitagishi Mutsumi Murakami Yuri Nishimura Satoru Matsuda |
| author_facet | Naoko Okumura Hitomi Yoshida Yasuko Kitagishi Mutsumi Murakami Yuri Nishimura Satoru Matsuda |
| author_sort | Naoko Okumura |
| collection | DOAJ |
| description | PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The mechanism by which the signaling pathway regulates angiogenesis remains to be further elucidated. However, it has become an attractive target for drug therapy against leukemia, because angiogenesis is a key process in malignant cell growth. In this paper, we will focus on the roles and mechanisms of PI3K/AKT/PTEN pathway in regulating angiogenesis. |
| format | Article |
| id | doaj-art-53d92cddec6848a386d2c5c0d998affb |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-53d92cddec6848a386d2c5c0d998affb2025-02-03T01:06:20ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/843085843085PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia AngiogenesisNaoko Okumura0Hitomi Yoshida1Yasuko Kitagishi2Mutsumi Murakami3Yuri Nishimura4Satoru Matsuda5Department of Environmental Health Science, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Environmental Health Science, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Environmental Health Science, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Environmental Health Science, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Environmental Health Science, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Environmental Health Science, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, JapanPI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The mechanism by which the signaling pathway regulates angiogenesis remains to be further elucidated. However, it has become an attractive target for drug therapy against leukemia, because angiogenesis is a key process in malignant cell growth. In this paper, we will focus on the roles and mechanisms of PI3K/AKT/PTEN pathway in regulating angiogenesis.http://dx.doi.org/10.1155/2012/843085 |
| spellingShingle | Naoko Okumura Hitomi Yoshida Yasuko Kitagishi Mutsumi Murakami Yuri Nishimura Satoru Matsuda PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis Advances in Hematology |
| title | PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis |
| title_full | PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis |
| title_fullStr | PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis |
| title_full_unstemmed | PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis |
| title_short | PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis |
| title_sort | pi3k akt pten signaling as a molecular target in leukemia angiogenesis |
| url | http://dx.doi.org/10.1155/2012/843085 |
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