Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study
Abstract Background Helicobacter pylori (Hp) infection and metabolic syndrome (MetS) have a high prevalence of co-morbidities and both pose a significant threat to human health and survival. It has been suggested that Hp infection affects the development of MetS in the host, but the causal relations...
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| Language: | English |
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BMC
2024-11-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-024-01519-1 |
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| author | Hongwei Wang Fangying Tian Caizheng Yang Xinyu Cui Yongxia Ding Ming Zhao Xueyu Wang Shanshan Ge |
| author_facet | Hongwei Wang Fangying Tian Caizheng Yang Xinyu Cui Yongxia Ding Ming Zhao Xueyu Wang Shanshan Ge |
| author_sort | Hongwei Wang |
| collection | DOAJ |
| description | Abstract Background Helicobacter pylori (Hp) infection and metabolic syndrome (MetS) have a high prevalence of co-morbidities and both pose a significant threat to human health and survival. It has been suggested that Hp infection affects the development of MetS in the host, but the causal relationship between the two has not been confirmed. Methods We conducted a two-sample Mendelian randomization study to investigate the causal effect of Hp infection with MetS and its components. Summary statistics for exposure factors (Hp infection) were obtained from the GWAS Catalog (anti-Hp IgG, n = 8,735; Hp VacA antibody levels, n = 1,571; Hp GroEL antibody levels, n = 2,716; Hp OMP antibody levels, n = 2,640). Summary statistics for outcome factors (MetS) were obtained from the most comprehensive genome-wide association study (GWAS) currently available (n = 291,107) as well as from the components of MetS: fasting glucose (n = 46,186), hypertension (n = 461,880), serum triglycerides (n = 115,082), waist circumference (n = 21,949), and high-density lipoprotein (n = 400, 754). The inverse-variance weighted (IVW) method was used as the primary MR method and the robustness of the results was assessed through sensitivity analyses. Results MR analysis showed that anti-Hp IgG levels were positively correlated with waist circumference (β = 0.08, P = 0.012), and GroEL antibody levels showed an opposite correlation with HDL levels (β= -0.03, P = 0.025) and TG (β = 0.02, P = 0.045). In contrast, OMP antibodies levels were positively correlated with both HDL and FBG (β = 0.064, P = 0.037 and β = 0.09, P = 0.003). In the estimation of IVW as the main causal method, VacA antibody level was positively associated with hypertension level and negatively associated with TG (β = 0.02, P = 0.008 and β= -0.02, P = 0.007). Meanwhile, the results of sensitivity analyses showed no heterogeneity or significant level pleiotropy. Conclusions Our study suggests that there is a causal effect between Hp infection and Mets diagnosis and its composition, and further studies are needed to understand the mechanism of its influence. |
| format | Article |
| id | doaj-art-53d6e287614f4376bfb6c935c6d85223 |
| institution | Kabale University |
| issn | 1758-5996 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-53d6e287614f4376bfb6c935c6d852232025-01-26T12:45:23ZengBMCDiabetology & Metabolic Syndrome1758-59962024-11-011611910.1186/s13098-024-01519-1Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization studyHongwei Wang0Fangying Tian1Caizheng Yang2Xinyu Cui3Yongxia Ding4Ming Zhao5Xueyu Wang6Shanshan Ge7Shanxi Medical UniversityInfection Management Department of the Second Hospital of Shanxi Medical UniversityShanxi Medical UniversityShanxi Medical UniversityShanxi Medical UniversityDepartment of Infectious Diseases, Ningxia Medical University General HospitalDepartment of Infectious Diseases, First Affiliated Hospital of Zhejiang University School of MedicineHealth Management Center of the First Hospital of Shanxi Medical UniversityAbstract Background Helicobacter pylori (Hp) infection and metabolic syndrome (MetS) have a high prevalence of co-morbidities and both pose a significant threat to human health and survival. It has been suggested that Hp infection affects the development of MetS in the host, but the causal relationship between the two has not been confirmed. Methods We conducted a two-sample Mendelian randomization study to investigate the causal effect of Hp infection with MetS and its components. Summary statistics for exposure factors (Hp infection) were obtained from the GWAS Catalog (anti-Hp IgG, n = 8,735; Hp VacA antibody levels, n = 1,571; Hp GroEL antibody levels, n = 2,716; Hp OMP antibody levels, n = 2,640). Summary statistics for outcome factors (MetS) were obtained from the most comprehensive genome-wide association study (GWAS) currently available (n = 291,107) as well as from the components of MetS: fasting glucose (n = 46,186), hypertension (n = 461,880), serum triglycerides (n = 115,082), waist circumference (n = 21,949), and high-density lipoprotein (n = 400, 754). The inverse-variance weighted (IVW) method was used as the primary MR method and the robustness of the results was assessed through sensitivity analyses. Results MR analysis showed that anti-Hp IgG levels were positively correlated with waist circumference (β = 0.08, P = 0.012), and GroEL antibody levels showed an opposite correlation with HDL levels (β= -0.03, P = 0.025) and TG (β = 0.02, P = 0.045). In contrast, OMP antibodies levels were positively correlated with both HDL and FBG (β = 0.064, P = 0.037 and β = 0.09, P = 0.003). In the estimation of IVW as the main causal method, VacA antibody level was positively associated with hypertension level and negatively associated with TG (β = 0.02, P = 0.008 and β= -0.02, P = 0.007). Meanwhile, the results of sensitivity analyses showed no heterogeneity or significant level pleiotropy. Conclusions Our study suggests that there is a causal effect between Hp infection and Mets diagnosis and its composition, and further studies are needed to understand the mechanism of its influence.https://doi.org/10.1186/s13098-024-01519-1Metabolic syndromeHelicobacter pylori infectionIntestinal flora imbalanceCausal associationsMendelian randomization |
| spellingShingle | Hongwei Wang Fangying Tian Caizheng Yang Xinyu Cui Yongxia Ding Ming Zhao Xueyu Wang Shanshan Ge Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study Diabetology & Metabolic Syndrome Metabolic syndrome Helicobacter pylori infection Intestinal flora imbalance Causal associations Mendelian randomization |
| title | Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study |
| title_full | Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study |
| title_fullStr | Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study |
| title_full_unstemmed | Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study |
| title_short | Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study |
| title_sort | causal associations of helicobacter pylori infection and metabolic syndrome insights from a two sample mendelian randomization study |
| topic | Metabolic syndrome Helicobacter pylori infection Intestinal flora imbalance Causal associations Mendelian randomization |
| url | https://doi.org/10.1186/s13098-024-01519-1 |
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