A hydrogel based herbal nanoformulation for enhanced wound healing
Abstract The aim of the present study is to develop a chitosan based herbal formulation using rhubarb for wound healing. Wound healing is a dynamic process facilitating the regeneration or repair of broken tissue. Rhubarb is commonly used worldwide for their effective antiseptic, antifungal and anti...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2025-01-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100303&lng=en&tlng=en |
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| author | Shaheen Sultana Nada Alzahrani Reem Alzahrani Wejdan Alshamrani Waad Aloufi Maria Khan Mohammad Yusuf |
| author_facet | Shaheen Sultana Nada Alzahrani Reem Alzahrani Wejdan Alshamrani Waad Aloufi Maria Khan Mohammad Yusuf |
| author_sort | Shaheen Sultana |
| collection | DOAJ |
| description | Abstract The aim of the present study is to develop a chitosan based herbal formulation using rhubarb for wound healing. Wound healing is a dynamic process facilitating the regeneration or repair of broken tissue. Rhubarb is commonly used worldwide for their effective antiseptic, antifungal and antiviral properties. Rhubarb loaded chitosan nanoparticles were prepared by ionic cross-linking process with sodium lauryl sulphate. The optimized formulation was examined for antibacterial activity against S. aureus and P. aeruginosa. Wound healing effects of the developed formulation was studied on excision wound model in Wistar albino rats. Average particle size and zeta potential of chitosan nanoparticles varied from 93 to 2,225 nm and from+30.82 to -16.08 mV, respectively. On the basis of particle size, zeta potential, and % entrapment, Formulation C 4 (0.0595% chitosan, 0.535% cross-linker, and 1% drug) was selected among different checkpoint formulation and further studies were performed. Hydrogel was developed using a combination of polyvinylpyrrolidone and carboxymethyl cellulose. Nanoformulation based hydrogel showed significantly enhanced antimicrobial activity against tested pathogenic microbial strains in comparison to drug solution, as well as marketed formulations. |
| format | Article |
| id | doaj-art-53b5aa9e79f54181ba1f0a648e4077b8 |
| institution | Kabale University |
| issn | 2175-9790 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj-art-53b5aa9e79f54181ba1f0a648e4077b82025-01-21T07:42:34ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902025-01-016110.1590/s2175-97902025e23625A hydrogel based herbal nanoformulation for enhanced wound healingShaheen Sultanahttps://orcid.org/0000-0002-5976-6751Nada AlzahraniReem AlzahraniWejdan AlshamraniWaad AloufiMaria Khanhttps://orcid.org/0000-0002-9948-0344Mohammad Yusufhttps://orcid.org/0000-0003-1417-7774Abstract The aim of the present study is to develop a chitosan based herbal formulation using rhubarb for wound healing. Wound healing is a dynamic process facilitating the regeneration or repair of broken tissue. Rhubarb is commonly used worldwide for their effective antiseptic, antifungal and antiviral properties. Rhubarb loaded chitosan nanoparticles were prepared by ionic cross-linking process with sodium lauryl sulphate. The optimized formulation was examined for antibacterial activity against S. aureus and P. aeruginosa. Wound healing effects of the developed formulation was studied on excision wound model in Wistar albino rats. Average particle size and zeta potential of chitosan nanoparticles varied from 93 to 2,225 nm and from+30.82 to -16.08 mV, respectively. On the basis of particle size, zeta potential, and % entrapment, Formulation C 4 (0.0595% chitosan, 0.535% cross-linker, and 1% drug) was selected among different checkpoint formulation and further studies were performed. Hydrogel was developed using a combination of polyvinylpyrrolidone and carboxymethyl cellulose. Nanoformulation based hydrogel showed significantly enhanced antimicrobial activity against tested pathogenic microbial strains in comparison to drug solution, as well as marketed formulations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100303&lng=en&tlng=enNanoparticlesRhubarbDesign ExpertWound healing |
| spellingShingle | Shaheen Sultana Nada Alzahrani Reem Alzahrani Wejdan Alshamrani Waad Aloufi Maria Khan Mohammad Yusuf A hydrogel based herbal nanoformulation for enhanced wound healing Brazilian Journal of Pharmaceutical Sciences Nanoparticles Rhubarb Design Expert Wound healing |
| title | A hydrogel based herbal nanoformulation for enhanced wound healing |
| title_full | A hydrogel based herbal nanoformulation for enhanced wound healing |
| title_fullStr | A hydrogel based herbal nanoformulation for enhanced wound healing |
| title_full_unstemmed | A hydrogel based herbal nanoformulation for enhanced wound healing |
| title_short | A hydrogel based herbal nanoformulation for enhanced wound healing |
| title_sort | hydrogel based herbal nanoformulation for enhanced wound healing |
| topic | Nanoparticles Rhubarb Design Expert Wound healing |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100303&lng=en&tlng=en |
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