Emerging Norovirus GII.12 infection in 2010 in Northern Taiwan
Norovirus (NoV) has been an emerging pathogen of enteric infections in the post-rotavirus vaccine era. GII.4 have played a major role in NoV infections while other genotypes were reported in sporadic outbreaks. In this study, we reported novel variant NoV GII.12 outbreaks in 2010, Taiwan with their...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of the Formosan Medical Association |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664624003449 |
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| author | Chi-Neu Tsai Yu-Chung Chang Hsun-Ching Chao Yi-Hsiang Hsu Yuan-Hung Wang Shih-Yen Chen |
| author_facet | Chi-Neu Tsai Yu-Chung Chang Hsun-Ching Chao Yi-Hsiang Hsu Yuan-Hung Wang Shih-Yen Chen |
| author_sort | Chi-Neu Tsai |
| collection | DOAJ |
| description | Norovirus (NoV) has been an emerging pathogen of enteric infections in the post-rotavirus vaccine era. GII.4 have played a major role in NoV infections while other genotypes were reported in sporadic outbreaks. In this study, we reported novel variant NoV GII.12 outbreaks in 2010, Taiwan with their genomic analysis and clinical manifestations compared to GII.4 infections.There were 30.5% (29 out of 95 cases) with NoV infection. The most common genotype was GII.4 (22, 75.9%) followed by GII.12 (5, 17.2%) and GII.3 (2, 6.9%). Phylogenetic analysis showed that our GII.12 sequences were closely aligned with reference genomes identified in the United Kingdom and the United States of America. When compared to patients infected by GII.4 NoV, those with GII.12 infection experienced a lower frequency and shorter duration of diarrhea. Continued research is essential to unravel the intricate relationship between NoV genotypes and clinical outcomes, guiding public health interventions and therapeutic strategies. |
| format | Article |
| id | doaj-art-53adf64b0d42421fa997e7e6aec5e09e |
| institution | Kabale University |
| issn | 0929-6646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj-art-53adf64b0d42421fa997e7e6aec5e09e2025-02-02T05:26:47ZengElsevierJournal of the Formosan Medical Association0929-66462025-02-011242186189Emerging Norovirus GII.12 infection in 2010 in Northern TaiwanChi-Neu Tsai0Yu-Chung Chang1Hsun-Ching Chao2Yi-Hsiang Hsu3Yuan-Hung Wang4Shih-Yen Chen5Graduate Institute of Clinical Medical Sciences, Chang Gung University, Kweishan, Taoyuan, TaiwanDepartment of Biotechnology, Ming-Chuan University, Taoyuan, TaiwanDivision of Pediatric Gastroenterology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, TaiwanBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USAGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taiwan; Department of Medical Research, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 23561, TaiwanDivision of Pediatric Gastroenterology, Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University, Taipei, 23561, Taiwan; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Corresponding author. Division of Pediatric Gastroenterology, Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University, Taipei, 23561, Taiwan.Norovirus (NoV) has been an emerging pathogen of enteric infections in the post-rotavirus vaccine era. GII.4 have played a major role in NoV infections while other genotypes were reported in sporadic outbreaks. In this study, we reported novel variant NoV GII.12 outbreaks in 2010, Taiwan with their genomic analysis and clinical manifestations compared to GII.4 infections.There were 30.5% (29 out of 95 cases) with NoV infection. The most common genotype was GII.4 (22, 75.9%) followed by GII.12 (5, 17.2%) and GII.3 (2, 6.9%). Phylogenetic analysis showed that our GII.12 sequences were closely aligned with reference genomes identified in the United Kingdom and the United States of America. When compared to patients infected by GII.4 NoV, those with GII.12 infection experienced a lower frequency and shorter duration of diarrhea. Continued research is essential to unravel the intricate relationship between NoV genotypes and clinical outcomes, guiding public health interventions and therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S0929664624003449 |
| spellingShingle | Chi-Neu Tsai Yu-Chung Chang Hsun-Ching Chao Yi-Hsiang Hsu Yuan-Hung Wang Shih-Yen Chen Emerging Norovirus GII.12 infection in 2010 in Northern Taiwan Journal of the Formosan Medical Association |
| title | Emerging Norovirus GII.12 infection in 2010 in Northern Taiwan |
| title_full | Emerging Norovirus GII.12 infection in 2010 in Northern Taiwan |
| title_fullStr | Emerging Norovirus GII.12 infection in 2010 in Northern Taiwan |
| title_full_unstemmed | Emerging Norovirus GII.12 infection in 2010 in Northern Taiwan |
| title_short | Emerging Norovirus GII.12 infection in 2010 in Northern Taiwan |
| title_sort | emerging norovirus gii 12 infection in 2010 in northern taiwan |
| url | http://www.sciencedirect.com/science/article/pii/S0929664624003449 |
| work_keys_str_mv | AT chineutsai emergingnorovirusgii12infectionin2010innortherntaiwan AT yuchungchang emergingnorovirusgii12infectionin2010innortherntaiwan AT hsunchingchao emergingnorovirusgii12infectionin2010innortherntaiwan AT yihsianghsu emergingnorovirusgii12infectionin2010innortherntaiwan AT yuanhungwang emergingnorovirusgii12infectionin2010innortherntaiwan AT shihyenchen emergingnorovirusgii12infectionin2010innortherntaiwan |