Secretion of cochlin-tomoprotein (LCCL) in the middle ear following acute tympanic injury: implications for perilymph fistula diagnosis

Secretion of cochlin-tomoprotein (LCCL) in the middle ear following acute tympanic injury: implications for perilymph fistula diagnosis

IntroductionCochlin is the most abundant protein in the inner ear. The cleaved N-terminal domain of cochlin, known as LCCL and referred to as CTP (cochlin tomoprotein) in clinical biomarker usage, is a perilymph-specific protein and is widely used as a biomarker to detect perilymph leakage. However,...

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Bibliographic Details
Main Authors: Seong Hoon Bae, Tetsuo Ikezono, Haeng Ran Park, Hyoyeol Kim, Tomohiro Matsumura, Shiho Saito, Yukihide Maeda, Han Matsuda, Jinsei Jung
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Neurology
Subjects:
cochlin tomoprotein
LCCL
perilymph
middle ear
tympanostomy
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1527311/full
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