Structural mechanism of DDX39B regulation by human TREX-2 and a related complex in mRNP remodeling

Structural mechanism of DDX39B regulation by human TREX-2 and a related complex in mRNP remodeling

Abstract Nuclear export of mRNAs in the form of messenger ribonucleoprotein particles (mRNPs) is an obligatory step for eukaryotic gene expression. The DEAD-box ATPase DDX39B (also known as UAP56) is a multifunctional regulator of nuclear mRNPs. How DDX39B mediates mRNP assembly and export in a cont...

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Main Authors: Bradley P. Clarke, Shengyan Gao, Menghan Mei, Dongqi Xie, Alexia E. Angelos, Ashley Vazhavilla, Pate S. Hill, Tolga Cagatay, Kimberly Batten, Jerry W. Shay, Yihu Xie, Beatriz M. A. Fontoura, Yi Ren
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60547-1
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