Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants
Purpose. This work aimed to synthesize the results of recent meta-analysis focusing on polymorphism in inflammatory mediators and its relation with the risk of periodontitis development. Materials and Methods. A systematic search was conducted using databases for publications prior to October 2016....
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2017/1914073 |
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| author | Maélson Klever da Silva Antonio Carlos Gonçalves de Carvalho Even Herlany Pereira Alves Felipe Rodolfo Pereira da Silva Larissa dos Santos Pessoa Daniel Fernando Pereira Vasconcelos |
| author_facet | Maélson Klever da Silva Antonio Carlos Gonçalves de Carvalho Even Herlany Pereira Alves Felipe Rodolfo Pereira da Silva Larissa dos Santos Pessoa Daniel Fernando Pereira Vasconcelos |
| author_sort | Maélson Klever da Silva |
| collection | DOAJ |
| description | Purpose. This work aimed to synthesize the results of recent meta-analysis focusing on polymorphism in inflammatory mediators and its relation with the risk of periodontitis development. Materials and Methods. A systematic search was conducted using databases for publications prior to October 2016. Three examiners extracted data from articles with a clear association between polymorphisms in the inflammatory mediator gene and the development of periodontitis through meta-analysis using the fixed or randomized statistical models to calculate the Odds Ratio with values of P<0.05 considered significant. Results. A total of 13 meta-analysis articles with 25 polymorphisms in seven interleukins (IL-1A, IL-1B, IL-4, IL-6, IL-8, IL-10, and IL-18), three cellular receptors (Fcγ receptors: FCGR2A, FCGR3A, and FCGR3B), and five inflammatory mediators (COX-2, MMP-2, MMP-3, MMP-8, and MMP-9), with a total of 71,531 participants, approaching different classifications of the disease. Conclusion. The study demonstrated that polymorphisms in the IL-1A, IL-1B, IL-6, IL-10, MMP-3 (chronic form), and MMP-9 (chronic form) polymorphisms were significantly associated with the risk of developing periodontitis, whereas other polymorphisms in the IL-4, IL-8, IL-18, Fcγ, COX-2, MMP-2, MMP-3 (aggressive), MMP-8, and MMP-9 (aggressive) polymorphisms had no significant association with risk of developing periodontitis. |
| format | Article |
| id | doaj-art-538de8cf3872421fb51173fd4b6ee33a |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-538de8cf3872421fb51173fd4b6ee33a2025-02-03T07:24:29ZengWileyInternational Journal of Dentistry1687-87281687-87362017-01-01201710.1155/2017/19140731914073Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 ParticipantsMaélson Klever da Silva0Antonio Carlos Gonçalves de Carvalho1Even Herlany Pereira Alves2Felipe Rodolfo Pereira da Silva3Larissa dos Santos Pessoa4Daniel Fernando Pereira Vasconcelos5Laboratory of Analysis and Histological Processing (LAPHIS), Federal University of Piaui, Parnaiba, PI, BrazilLaboratory of Analysis and Histological Processing (LAPHIS), Federal University of Piaui, Parnaiba, PI, BrazilLaboratory of Analysis and Histological Processing (LAPHIS), Federal University of Piaui, Parnaiba, PI, BrazilLaboratory of Analysis and Histological Processing (LAPHIS), Federal University of Piaui, Parnaiba, PI, BrazilLaboratory of Analysis and Histological Processing (LAPHIS), Federal University of Piaui, Parnaiba, PI, BrazilLaboratory of Analysis and Histological Processing (LAPHIS), Federal University of Piaui, Parnaiba, PI, BrazilPurpose. This work aimed to synthesize the results of recent meta-analysis focusing on polymorphism in inflammatory mediators and its relation with the risk of periodontitis development. Materials and Methods. A systematic search was conducted using databases for publications prior to October 2016. Three examiners extracted data from articles with a clear association between polymorphisms in the inflammatory mediator gene and the development of periodontitis through meta-analysis using the fixed or randomized statistical models to calculate the Odds Ratio with values of P<0.05 considered significant. Results. A total of 13 meta-analysis articles with 25 polymorphisms in seven interleukins (IL-1A, IL-1B, IL-4, IL-6, IL-8, IL-10, and IL-18), three cellular receptors (Fcγ receptors: FCGR2A, FCGR3A, and FCGR3B), and five inflammatory mediators (COX-2, MMP-2, MMP-3, MMP-8, and MMP-9), with a total of 71,531 participants, approaching different classifications of the disease. Conclusion. The study demonstrated that polymorphisms in the IL-1A, IL-1B, IL-6, IL-10, MMP-3 (chronic form), and MMP-9 (chronic form) polymorphisms were significantly associated with the risk of developing periodontitis, whereas other polymorphisms in the IL-4, IL-8, IL-18, Fcγ, COX-2, MMP-2, MMP-3 (aggressive), MMP-8, and MMP-9 (aggressive) polymorphisms had no significant association with risk of developing periodontitis.http://dx.doi.org/10.1155/2017/1914073 |
| spellingShingle | Maélson Klever da Silva Antonio Carlos Gonçalves de Carvalho Even Herlany Pereira Alves Felipe Rodolfo Pereira da Silva Larissa dos Santos Pessoa Daniel Fernando Pereira Vasconcelos Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants International Journal of Dentistry |
| title | Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants |
| title_full | Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants |
| title_fullStr | Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants |
| title_full_unstemmed | Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants |
| title_short | Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants |
| title_sort | genetic factors and the risk of periodontitis development findings from a systematic review composed of 13 studies of meta analysis with 71 531 participants |
| url | http://dx.doi.org/10.1155/2017/1914073 |
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