Quercetin Attenuates Oxidative Stress and Apoptosis in Brain Tissue of APP/PS1 Double Transgenic AD Mice by Regulating Keap1/Nrf2/HO-1 Pathway to Improve Cognitive Impairment
Conclusion: Quercetin can improve cognitive impairment and AD-like pathology in APP/PS1 double transgenic mice, potentially related to quercetin’s activation of the Keap1/Nrf2/HO-1 pathway and reduction of cell apoptosis.
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2024/5698119 |
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| _version_ | 1832544196726095872 |
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| author | Meijia Cheng Changbin Yuan Yetao Ju Yongming Liu Baorui Shi Yali Yang Sian Jin Xiaoming He Li Zhang Dongyu Min |
| author_facet | Meijia Cheng Changbin Yuan Yetao Ju Yongming Liu Baorui Shi Yali Yang Sian Jin Xiaoming He Li Zhang Dongyu Min |
| author_sort | Meijia Cheng |
| collection | DOAJ |
| description | Conclusion: Quercetin can improve cognitive impairment and AD-like pathology in APP/PS1 double transgenic mice, potentially related to quercetin’s activation of the Keap1/Nrf2/HO-1 pathway and reduction of cell apoptosis. |
| format | Article |
| id | doaj-art-5387ed5abcaf47f98563645b33bef48d |
| institution | Kabale University |
| issn | 1875-8584 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-5387ed5abcaf47f98563645b33bef48d2025-02-03T10:52:36ZengWileyBehavioural Neurology1875-85842024-01-01202410.1155/2024/5698119Quercetin Attenuates Oxidative Stress and Apoptosis in Brain Tissue of APP/PS1 Double Transgenic AD Mice by Regulating Keap1/Nrf2/HO-1 Pathway to Improve Cognitive ImpairmentMeijia Cheng0Changbin Yuan1Yetao Ju2Yongming Liu3Baorui Shi4Yali Yang5Sian Jin6Xiaoming He7Li Zhang8Dongyu Min9Affiliated Hospital of Liaoning University of Traditional Chinese MedicineLiaoning University of Traditional Chinese MedicineAffiliated Hospital of Liaoning University of Traditional Chinese MedicineAffiliated Hospital of Liaoning University of Traditional Chinese MedicineLiaoning University of Traditional Chinese MedicineLiaoning University of Traditional Chinese MedicineLiaoning University of Traditional Chinese MedicineLiaoning University of Traditional Chinese MedicineLiaoning University of Traditional Chinese MedicineKey Laboratory of Ministry of Education for TCM Viscera-State Theory and ApplicationsConclusion: Quercetin can improve cognitive impairment and AD-like pathology in APP/PS1 double transgenic mice, potentially related to quercetin’s activation of the Keap1/Nrf2/HO-1 pathway and reduction of cell apoptosis.http://dx.doi.org/10.1155/2024/5698119 |
| spellingShingle | Meijia Cheng Changbin Yuan Yetao Ju Yongming Liu Baorui Shi Yali Yang Sian Jin Xiaoming He Li Zhang Dongyu Min Quercetin Attenuates Oxidative Stress and Apoptosis in Brain Tissue of APP/PS1 Double Transgenic AD Mice by Regulating Keap1/Nrf2/HO-1 Pathway to Improve Cognitive Impairment Behavioural Neurology |
| title | Quercetin Attenuates Oxidative Stress and Apoptosis in Brain Tissue of APP/PS1 Double Transgenic AD Mice by Regulating Keap1/Nrf2/HO-1 Pathway to Improve Cognitive Impairment |
| title_full | Quercetin Attenuates Oxidative Stress and Apoptosis in Brain Tissue of APP/PS1 Double Transgenic AD Mice by Regulating Keap1/Nrf2/HO-1 Pathway to Improve Cognitive Impairment |
| title_fullStr | Quercetin Attenuates Oxidative Stress and Apoptosis in Brain Tissue of APP/PS1 Double Transgenic AD Mice by Regulating Keap1/Nrf2/HO-1 Pathway to Improve Cognitive Impairment |
| title_full_unstemmed | Quercetin Attenuates Oxidative Stress and Apoptosis in Brain Tissue of APP/PS1 Double Transgenic AD Mice by Regulating Keap1/Nrf2/HO-1 Pathway to Improve Cognitive Impairment |
| title_short | Quercetin Attenuates Oxidative Stress and Apoptosis in Brain Tissue of APP/PS1 Double Transgenic AD Mice by Regulating Keap1/Nrf2/HO-1 Pathway to Improve Cognitive Impairment |
| title_sort | quercetin attenuates oxidative stress and apoptosis in brain tissue of app ps1 double transgenic ad mice by regulating keap1 nrf2 ho 1 pathway to improve cognitive impairment |
| url | http://dx.doi.org/10.1155/2024/5698119 |
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