The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome
Obstructive sleep apnoea syndrome (OSAS) is a chronic inflammatory disease regulated by T lymphocytes. Our purpose is to assess the pattern of Th17 cells and CD4+CD25+Foxp3+ regulatory T (Treg) cells in peripheral blood of patients with OSAS. Fourty-four OSAS men and 20 healthy volunteers were enrol...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/815308 |
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| author | Jin Ye Hui Liu Gehua Zhang Peng Li Zhiyuan Wang Shaotong Huang Qintai Yang Yuan Li |
| author_facet | Jin Ye Hui Liu Gehua Zhang Peng Li Zhiyuan Wang Shaotong Huang Qintai Yang Yuan Li |
| author_sort | Jin Ye |
| collection | DOAJ |
| description | Obstructive sleep apnoea syndrome (OSAS) is a chronic inflammatory disease regulated by T lymphocytes. Our purpose is to assess the pattern of Th17 cells and CD4+CD25+Foxp3+ regulatory T (Treg) cells in peripheral blood of patients with OSAS. Fourty-four OSAS men and 20 healthy volunteers were enrolled. Twenty-three patients were classified into mild to moderate group and 21 cases were classified into severe group according to the severity of OSAS. We detected the frequencies of Th17 and Treg and related serum cytokines secretion and expressions of key transcription factors. OSAS patients revealed significant increase in peripheral Th17 number, Th17-related cytokines (IL-17 and IL-6), and RORγt mRNA levels. They also presented a significant decrease in Treg number, Treg-related cytokines (TGF-β1), and Foxp3 mRNA levels as compared with normal persons. As a result, the Th17/Treg ratios were markedly more upregulated in OSAS patients than those in control group. Furthermore, the Th17/Treg ratio was positively related to the severity of OSAS and serum levels of C-reactive protein. The development of OSAS may be associated with peripheral Th17/Treg imbalance and characterized by a proinflammatory cytokine microenvironment. These results opened an alternative explanation for the substantial activation of immune cells in OSAS and the development of related complications. |
| format | Article |
| id | doaj-art-5383650dd5fb4b3181e2718288e5fcf4 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5383650dd5fb4b3181e2718288e5fcf42025-02-03T05:45:40ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/815308815308The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea SyndromeJin Ye0Hui Liu1Gehua Zhang2Peng Li3Zhiyuan Wang4Shaotong Huang5Qintai Yang6Yuan Li7Sleep Disorders Centre and Department of Otolaryngology—Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong 510630, ChinaDivision of Pulmonary and Critical Care, Department of Internal Medicine, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong 510630, ChinaSleep Disorders Centre and Department of Otolaryngology—Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong 510630, ChinaSleep Disorders Centre and Department of Otolaryngology—Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong 510630, ChinaSleep Disorders Centre and Department of Otolaryngology—Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong 510630, ChinaSleep Disorders Centre, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong 510630, ChinaSleep Disorders Centre and Department of Otolaryngology—Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong 510630, ChinaSleep Disorders Centre and Department of Otolaryngology—Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Street, Guangzhou, Guangdong 510630, ChinaObstructive sleep apnoea syndrome (OSAS) is a chronic inflammatory disease regulated by T lymphocytes. Our purpose is to assess the pattern of Th17 cells and CD4+CD25+Foxp3+ regulatory T (Treg) cells in peripheral blood of patients with OSAS. Fourty-four OSAS men and 20 healthy volunteers were enrolled. Twenty-three patients were classified into mild to moderate group and 21 cases were classified into severe group according to the severity of OSAS. We detected the frequencies of Th17 and Treg and related serum cytokines secretion and expressions of key transcription factors. OSAS patients revealed significant increase in peripheral Th17 number, Th17-related cytokines (IL-17 and IL-6), and RORγt mRNA levels. They also presented a significant decrease in Treg number, Treg-related cytokines (TGF-β1), and Foxp3 mRNA levels as compared with normal persons. As a result, the Th17/Treg ratios were markedly more upregulated in OSAS patients than those in control group. Furthermore, the Th17/Treg ratio was positively related to the severity of OSAS and serum levels of C-reactive protein. The development of OSAS may be associated with peripheral Th17/Treg imbalance and characterized by a proinflammatory cytokine microenvironment. These results opened an alternative explanation for the substantial activation of immune cells in OSAS and the development of related complications.http://dx.doi.org/10.1155/2012/815308 |
| spellingShingle | Jin Ye Hui Liu Gehua Zhang Peng Li Zhiyuan Wang Shaotong Huang Qintai Yang Yuan Li The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome Mediators of Inflammation |
| title | The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome |
| title_full | The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome |
| title_fullStr | The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome |
| title_full_unstemmed | The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome |
| title_short | The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome |
| title_sort | treg th17 imbalance in patients with obstructive sleep apnoea syndrome |
| url | http://dx.doi.org/10.1155/2012/815308 |
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