Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility
Glass-ceramic scaffolds containing Mg have shown recently the potential to enhance the proliferation, differentiation, and biomineralization of stem cells in vitro, property that makes them promising candidates for dental tissue regeneration. An additional property of a scaffold aimed at dental tiss...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2016/3858301 |
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| author | Georgios S. Theodorou Eleana Kontonasaki Anna Theocharidou Athina Bakopoulou Maria Bousnaki Christina Hadjichristou Eleni Papachristou Lambrini Papadopoulou Nikolaos A. Kantiranis Konstantinos Chrissafis Konstantinos M. Paraskevopoulos Petros T. Koidis |
| author_facet | Georgios S. Theodorou Eleana Kontonasaki Anna Theocharidou Athina Bakopoulou Maria Bousnaki Christina Hadjichristou Eleni Papachristou Lambrini Papadopoulou Nikolaos A. Kantiranis Konstantinos Chrissafis Konstantinos M. Paraskevopoulos Petros T. Koidis |
| author_sort | Georgios S. Theodorou |
| collection | DOAJ |
| description | Glass-ceramic scaffolds containing Mg have shown recently the potential to enhance the proliferation, differentiation, and biomineralization of stem cells in vitro, property that makes them promising candidates for dental tissue regeneration. An additional property of a scaffold aimed at dental tissue regeneration is to protect the regeneration process against oral bacteria penetration. In this respect, novel bioactive scaffolds containing Mg2+ and Cu2+ or Zn2+, ions known for their antimicrobial properties, were synthesized by the foam replica technique and tested regarding their bioactive response in SBF, mechanical properties, degradation, and porosity. Finally their ability to support the attachment and long-term proliferation of Dental Pulp Stem Cells (DPSCs) was also evaluated. The results showed that conversely to their bioactive response in SBF solution, Zn-doped scaffolds proved to respond adequately regarding their mechanical strength and to be efficient regarding their biological response, in comparison to Cu-doped scaffolds, which makes them promising candidates for targeted dental stem cell odontogenic differentiation and calcified dental tissue engineering. |
| format | Article |
| id | doaj-art-53701ac34d2149719ecfdede0c7f3bc2 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-53701ac34d2149719ecfdede0c7f3bc22025-02-03T01:24:28ZengWileyInternational Journal of Biomaterials1687-87871687-87952016-01-01201610.1155/2016/38583013858301Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and BiocompatibilityGeorgios S. Theodorou0Eleana Kontonasaki1Anna Theocharidou2Athina Bakopoulou3Maria Bousnaki4Christina Hadjichristou5Eleni Papachristou6Lambrini Papadopoulou7Nikolaos A. Kantiranis8Konstantinos Chrissafis9Konstantinos M. Paraskevopoulos10Petros T. Koidis11Department of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDentistry Department, Laboratory of Fixed Prosthesis and Implant Prosthodontics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDentistry Department, Laboratory of Fixed Prosthesis and Implant Prosthodontics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDentistry Department, Laboratory of Fixed Prosthesis and Implant Prosthodontics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDentistry Department, Laboratory of Fixed Prosthesis and Implant Prosthodontics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDentistry Department, Laboratory of Fixed Prosthesis and Implant Prosthodontics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDentistry Department, Laboratory of Fixed Prosthesis and Implant Prosthodontics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Geology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Geology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDentistry Department, Laboratory of Fixed Prosthesis and Implant Prosthodontics, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceGlass-ceramic scaffolds containing Mg have shown recently the potential to enhance the proliferation, differentiation, and biomineralization of stem cells in vitro, property that makes them promising candidates for dental tissue regeneration. An additional property of a scaffold aimed at dental tissue regeneration is to protect the regeneration process against oral bacteria penetration. In this respect, novel bioactive scaffolds containing Mg2+ and Cu2+ or Zn2+, ions known for their antimicrobial properties, were synthesized by the foam replica technique and tested regarding their bioactive response in SBF, mechanical properties, degradation, and porosity. Finally their ability to support the attachment and long-term proliferation of Dental Pulp Stem Cells (DPSCs) was also evaluated. The results showed that conversely to their bioactive response in SBF solution, Zn-doped scaffolds proved to respond adequately regarding their mechanical strength and to be efficient regarding their biological response, in comparison to Cu-doped scaffolds, which makes them promising candidates for targeted dental stem cell odontogenic differentiation and calcified dental tissue engineering.http://dx.doi.org/10.1155/2016/3858301 |
| spellingShingle | Georgios S. Theodorou Eleana Kontonasaki Anna Theocharidou Athina Bakopoulou Maria Bousnaki Christina Hadjichristou Eleni Papachristou Lambrini Papadopoulou Nikolaos A. Kantiranis Konstantinos Chrissafis Konstantinos M. Paraskevopoulos Petros T. Koidis Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility International Journal of Biomaterials |
| title | Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility |
| title_full | Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility |
| title_fullStr | Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility |
| title_full_unstemmed | Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility |
| title_short | Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility |
| title_sort | sol gel derived mg based ceramic scaffolds doped with zinc or copper ions preliminary results on their synthesis characterization and biocompatibility |
| url | http://dx.doi.org/10.1155/2016/3858301 |
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