Applications of cell penetrating peptide-based drug delivery system in immunotherapy
Cell penetrating peptides (CPPs) are usually positive charged peptides and have good cell membrane permeability. Meanwhile, CPPs are facile to synthesize, and can be functionalized to satisfy different demands, such as cyclization, incorporating unnatural amino acids, and lipid conjugation. These pr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1540192/full |
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| author | Jing-Jing Du Ru-Yan Zhang Shangchi Jiang Shanshan Xiao Yiting Liu Yongheng Niu Wen-Xiang Zhao Dongyuan Wang Dongyuan Wang XianShi Ma |
| author_facet | Jing-Jing Du Ru-Yan Zhang Shangchi Jiang Shanshan Xiao Yiting Liu Yongheng Niu Wen-Xiang Zhao Dongyuan Wang Dongyuan Wang XianShi Ma |
| author_sort | Jing-Jing Du |
| collection | DOAJ |
| description | Cell penetrating peptides (CPPs) are usually positive charged peptides and have good cell membrane permeability. Meanwhile, CPPs are facile to synthesize, and can be functionalized to satisfy different demands, such as cyclization, incorporating unnatural amino acids, and lipid conjugation. These properties have made them as efficient drug-delivery tools to deliver therapeutic molecules to cells and tissues in a nontoxic manner, including small molecules, DNA, siRNA, therapeutic proteins and other various nanoparticles. However, the poor serum stability and low tumor targeting ability also hindered their broad application. Besides, inappropriate chemical modification can lead to membrane disruption and nonspecific toxicity. In this paper, we first reviewed recent advances in the CPP applications for cancer therapy via covalent or non-covalent manners. We carefully analyzed the advantages and disadvantages of each CPP modifications for drug delivery. Then, we concluded the recent progress of their clinical trials for different diseases. Finally, we discussed the challenges and opportunities CPPs met to translate into clinical applications. This review presented a new insight into CPPs for drug delivery, which could provide advice on the design of clinically effective systemic delivery systems using CPPs. |
| format | Article |
| id | doaj-art-53654f5aa8a145fea8e8d4dfd5ac3410 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-53654f5aa8a145fea8e8d4dfd5ac34102025-01-22T07:12:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15401921540192Applications of cell penetrating peptide-based drug delivery system in immunotherapyJing-Jing Du0Ru-Yan Zhang1Shangchi Jiang2Shanshan Xiao3Yiting Liu4Yongheng Niu5Wen-Xiang Zhao6Dongyuan Wang7Dongyuan Wang8XianShi Ma9Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, College of Medicine, Hubei Polytechnic University, Huangshi, ChinaHubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, College of Medicine, Hubei Polytechnic University, Huangshi, ChinaHubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, College of Medicine, Hubei Polytechnic University, Huangshi, ChinaHubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, College of Medicine, Hubei Polytechnic University, Huangshi, ChinaHubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, College of Medicine, Hubei Polytechnic University, Huangshi, ChinaHubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, College of Medicine, Hubei Polytechnic University, Huangshi, ChinaHubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, College of Medicine, Hubei Polytechnic University, Huangshi, ChinaDepartment of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan, ChinaDepartment of Hepatobiliary Surgery, Yangxin County People’s Hospital, Huangshi, ChinaCell penetrating peptides (CPPs) are usually positive charged peptides and have good cell membrane permeability. Meanwhile, CPPs are facile to synthesize, and can be functionalized to satisfy different demands, such as cyclization, incorporating unnatural amino acids, and lipid conjugation. These properties have made them as efficient drug-delivery tools to deliver therapeutic molecules to cells and tissues in a nontoxic manner, including small molecules, DNA, siRNA, therapeutic proteins and other various nanoparticles. However, the poor serum stability and low tumor targeting ability also hindered their broad application. Besides, inappropriate chemical modification can lead to membrane disruption and nonspecific toxicity. In this paper, we first reviewed recent advances in the CPP applications for cancer therapy via covalent or non-covalent manners. We carefully analyzed the advantages and disadvantages of each CPP modifications for drug delivery. Then, we concluded the recent progress of their clinical trials for different diseases. Finally, we discussed the challenges and opportunities CPPs met to translate into clinical applications. This review presented a new insight into CPPs for drug delivery, which could provide advice on the design of clinically effective systemic delivery systems using CPPs.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1540192/fullcell penetration peptidecovalent conjugationnon-covalent deliverycancer immunotherapyclinical application |
| spellingShingle | Jing-Jing Du Ru-Yan Zhang Shangchi Jiang Shanshan Xiao Yiting Liu Yongheng Niu Wen-Xiang Zhao Dongyuan Wang Dongyuan Wang XianShi Ma Applications of cell penetrating peptide-based drug delivery system in immunotherapy Frontiers in Immunology cell penetration peptide covalent conjugation non-covalent delivery cancer immunotherapy clinical application |
| title | Applications of cell penetrating peptide-based drug delivery system in immunotherapy |
| title_full | Applications of cell penetrating peptide-based drug delivery system in immunotherapy |
| title_fullStr | Applications of cell penetrating peptide-based drug delivery system in immunotherapy |
| title_full_unstemmed | Applications of cell penetrating peptide-based drug delivery system in immunotherapy |
| title_short | Applications of cell penetrating peptide-based drug delivery system in immunotherapy |
| title_sort | applications of cell penetrating peptide based drug delivery system in immunotherapy |
| topic | cell penetration peptide covalent conjugation non-covalent delivery cancer immunotherapy clinical application |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1540192/full |
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