Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets
A method for the quantitative determination of dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), bis(2-ethylhexyl) adipate (DEHA), bis(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), dioctyl terephthalate (DOTP), diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP) in medic...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2018/9470254 |
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| author | So Hyeon Jeon Yong Pyo Kim Younglim Kho Jeoung Hwa Shin Won Hyun Ji Yun Gyong Ahn |
| author_facet | So Hyeon Jeon Yong Pyo Kim Younglim Kho Jeoung Hwa Shin Won Hyun Ji Yun Gyong Ahn |
| author_sort | So Hyeon Jeon |
| collection | DOAJ |
| description | A method for the quantitative determination of dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), bis(2-ethylhexyl) adipate (DEHA), bis(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), dioctyl terephthalate (DOTP), diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP) in medical infusion sets was developed and validated using gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS) in the multiple reaction monitoring (MRM) mode. Solvent extraction with polymer dissolution for sample preparation was employed prior to GC-MS/MS analysis. Average recoveries of the eight target analytes are typically in the range of 91.8–122% with the relative standard deviations of 1.8–17.8%. The limits of quantification (LOQs) of the analytical method were in the ranges of 54.1 to 76.3 ng/g. Analysis using GC-MS/MS provided reliable performance, as well as higher sensitivity and selectivity than GC-MS analysis, especially for the presence of minority plasticizers at different concentrations. |
| format | Article |
| id | doaj-art-53637bc4ba1f4123bfa363788e88e3da |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-53637bc4ba1f4123bfa363788e88e3da2025-02-03T01:25:50ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732018-01-01201810.1155/2018/94702549470254Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion SetsSo Hyeon Jeon0Yong Pyo Kim1Younglim Kho2Jeoung Hwa Shin3Won Hyun Ji4Yun Gyong Ahn5Western Seoul Center, Korea Basic Science Institute, Seoul 03759, Republic of KoreaDepartment of Chemical Engineering and Material Science, Ewha Womans University, Seoul 03760, Republic of KoreaDepartment of Health, Environment & Safety, Eulji University, Seongnam 13135, Republic of KoreaSeoul Center, Korea Basic Science Institute, Seoul 02841, Republic of KoreaInstitute of Mine Reclamation Technology, Mine Reclamation Corporation, Wonju 26464, Republic of KoreaWestern Seoul Center, Korea Basic Science Institute, Seoul 03759, Republic of KoreaA method for the quantitative determination of dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), bis(2-ethylhexyl) adipate (DEHA), bis(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), dioctyl terephthalate (DOTP), diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP) in medical infusion sets was developed and validated using gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS) in the multiple reaction monitoring (MRM) mode. Solvent extraction with polymer dissolution for sample preparation was employed prior to GC-MS/MS analysis. Average recoveries of the eight target analytes are typically in the range of 91.8–122% with the relative standard deviations of 1.8–17.8%. The limits of quantification (LOQs) of the analytical method were in the ranges of 54.1 to 76.3 ng/g. Analysis using GC-MS/MS provided reliable performance, as well as higher sensitivity and selectivity than GC-MS analysis, especially for the presence of minority plasticizers at different concentrations.http://dx.doi.org/10.1155/2018/9470254 |
| spellingShingle | So Hyeon Jeon Yong Pyo Kim Younglim Kho Jeoung Hwa Shin Won Hyun Ji Yun Gyong Ahn Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets Journal of Analytical Methods in Chemistry |
| title | Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets |
| title_full | Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets |
| title_fullStr | Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets |
| title_full_unstemmed | Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets |
| title_short | Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets |
| title_sort | development and validation of gas chromatography triple quadrupole mass spectrometric method for quantitative determination of regulated plasticizers in medical infusion sets |
| url | http://dx.doi.org/10.1155/2018/9470254 |
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