Lethal Clostridium difficile Colitis Associated with Paclitaxel and Carboplatin Chemotherapy in Ovarian Carcinoma: Case Report and Review of the Literature
Clostridium difficile colitis, although rare, could represent a serious complication following chemotherapy. Prior antibiotic use has been considered the single most important risk factor in the development of C. difficile infection. Recently, the association between antineoplastic therapy and C. di...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2010/749789 |
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| author | V. Masciullo S. Mainenti D. Lorusso P. A. Margariti G. Scambia |
| author_facet | V. Masciullo S. Mainenti D. Lorusso P. A. Margariti G. Scambia |
| author_sort | V. Masciullo |
| collection | DOAJ |
| description | Clostridium difficile colitis, although rare, could represent a serious complication following chemotherapy. Prior antibiotic use has been considered the single most important risk factor in the development of C. difficile infection. Recently, the association between antineoplastic therapy and C. difficile-associated diarrhea in the absence of a prior antibiotic therapy has become more apparent. A 75-year-old woman with serous adenocarcinoma of the ovary developed lethal pancolitis caused by C. difficile after five cycles of paclitaxel- and carboplatin-based chemotherapy. She presented with diarrhea, coffee-ground emesis, and oliguria and was hospitalized immediately for aggressive treatment. Despite all the medical efforts, her condition worsened and she died after twenty days. We describe the second case reported of a patient developing a severe C. difficile colitis following chemotherapy without any recent antibiotic use and review the data of the literature, emphasizing the need to a prompt diagnosis and management that can significantly decrease the morbidity and life-threatening complications associated with this infection. |
| format | Article |
| id | doaj-art-5357487a3ec1460eade94579d103c324 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-5357487a3ec1460eade94579d103c3242025-02-03T01:24:31ZengWileyObstetrics and Gynecology International1687-95891687-95972010-01-01201010.1155/2010/749789749789Lethal Clostridium difficile Colitis Associated with Paclitaxel and Carboplatin Chemotherapy in Ovarian Carcinoma: Case Report and Review of the LiteratureV. Masciullo0S. Mainenti1D. Lorusso2P. A. Margariti3G. Scambia4Division of Gynecologic Oncology, Catholic University of Sacred Heart, L. go A. Gemelli, 8, 00168 Rome, ItalyDivision of Gynecologic Oncology, Catholic University of Sacred Heart, L. go A. Gemelli, 8, 00168 Rome, ItalyDivision of Gynecologic Oncology, Catholic University of Sacred Heart, L. go A. Gemelli, 8, 00168 Rome, ItalyDivision of Gynecologic Oncology, Catholic University of Sacred Heart, L. go A. Gemelli, 8, 00168 Rome, ItalyDivision of Gynecologic Oncology, Catholic University of Sacred Heart, L. go A. Gemelli, 8, 00168 Rome, ItalyClostridium difficile colitis, although rare, could represent a serious complication following chemotherapy. Prior antibiotic use has been considered the single most important risk factor in the development of C. difficile infection. Recently, the association between antineoplastic therapy and C. difficile-associated diarrhea in the absence of a prior antibiotic therapy has become more apparent. A 75-year-old woman with serous adenocarcinoma of the ovary developed lethal pancolitis caused by C. difficile after five cycles of paclitaxel- and carboplatin-based chemotherapy. She presented with diarrhea, coffee-ground emesis, and oliguria and was hospitalized immediately for aggressive treatment. Despite all the medical efforts, her condition worsened and she died after twenty days. We describe the second case reported of a patient developing a severe C. difficile colitis following chemotherapy without any recent antibiotic use and review the data of the literature, emphasizing the need to a prompt diagnosis and management that can significantly decrease the morbidity and life-threatening complications associated with this infection.http://dx.doi.org/10.1155/2010/749789 |
| spellingShingle | V. Masciullo S. Mainenti D. Lorusso P. A. Margariti G. Scambia Lethal Clostridium difficile Colitis Associated with Paclitaxel and Carboplatin Chemotherapy in Ovarian Carcinoma: Case Report and Review of the Literature Obstetrics and Gynecology International |
| title | Lethal Clostridium difficile Colitis Associated with Paclitaxel and Carboplatin Chemotherapy in Ovarian Carcinoma: Case Report and Review of the Literature |
| title_full | Lethal Clostridium difficile Colitis Associated with Paclitaxel and Carboplatin Chemotherapy in Ovarian Carcinoma: Case Report and Review of the Literature |
| title_fullStr | Lethal Clostridium difficile Colitis Associated with Paclitaxel and Carboplatin Chemotherapy in Ovarian Carcinoma: Case Report and Review of the Literature |
| title_full_unstemmed | Lethal Clostridium difficile Colitis Associated with Paclitaxel and Carboplatin Chemotherapy in Ovarian Carcinoma: Case Report and Review of the Literature |
| title_short | Lethal Clostridium difficile Colitis Associated with Paclitaxel and Carboplatin Chemotherapy in Ovarian Carcinoma: Case Report and Review of the Literature |
| title_sort | lethal clostridium difficile colitis associated with paclitaxel and carboplatin chemotherapy in ovarian carcinoma case report and review of the literature |
| url | http://dx.doi.org/10.1155/2010/749789 |
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