In search of Alzheimer’s disease treatment methods: trends of clinical trials
There is a strong necessity to develop new treatments for Alzheimer’s disease (AD) as its frequency is rapidly growing with the ageing population. There were 25 pharmacological agents involved in phase I trials, 52 in phase II, and 28 agents in phase III clinical trials in 2017. More than two third...
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| Format: | Article |
| Language: | English |
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Vilnius University Press
2018-03-01
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| Series: | Neurologijos seminarai |
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| Online Access: | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27849 |
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| author | G. Pakulaitė V. Regelskytė E. Audronytė J. Kuzmickienė G. Kaubrys |
| author_facet | G. Pakulaitė V. Regelskytė E. Audronytė J. Kuzmickienė G. Kaubrys |
| author_sort | G. Pakulaitė |
| collection | DOAJ |
| description |
There is a strong necessity to develop new treatments for Alzheimer’s disease (AD) as its frequency is rapidly growing with the ageing population. There were 25 pharmacological agents involved in phase I trials, 52 in phase II, and 28 agents in phase III clinical trials in 2017. More than two thirds (70%) of these agents are developed as disease-modifying therapies. Their mechanisms of action are targeted mainly to amyloid and tau related pathology. Almost one third (27%) of the agents comprise the group of symptomatic treatment. There is a number of factors that determine the current failure of the research. The factors include incomplete understanding of AD pathophysiology, limited agent access to the central nervous system, and lack of diagnostic and predictive biomarkers. Although AD treatment studies have given no clear positive results in recent decades, research is actively continued due to the growing economic and social burden of the disease.
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| format | Article |
| id | doaj-art-535355bcf8ee4f2dae23cd32837c3430 |
| institution | Kabale University |
| issn | 1392-3064 2424-5917 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Neurologijos seminarai |
| spelling | doaj-art-535355bcf8ee4f2dae23cd32837c34302025-01-20T18:23:20ZengVilnius University PressNeurologijos seminarai1392-30642424-59172018-03-01221(75)10.29014/ns.2018.03In search of Alzheimer’s disease treatment methods: trends of clinical trialsG. Pakulaitė 0V. Regelskytė 1E. Audronytė 2J. Kuzmickienė 3G. Kaubrys4Vilnius University, LithuaniaVilnius University, LithuaniaVilnius University, LithuaniaVilnius University, LithuaniaVilnius University, Lithuania There is a strong necessity to develop new treatments for Alzheimer’s disease (AD) as its frequency is rapidly growing with the ageing population. There were 25 pharmacological agents involved in phase I trials, 52 in phase II, and 28 agents in phase III clinical trials in 2017. More than two thirds (70%) of these agents are developed as disease-modifying therapies. Their mechanisms of action are targeted mainly to amyloid and tau related pathology. Almost one third (27%) of the agents comprise the group of symptomatic treatment. There is a number of factors that determine the current failure of the research. The factors include incomplete understanding of AD pathophysiology, limited agent access to the central nervous system, and lack of diagnostic and predictive biomarkers. Although AD treatment studies have given no clear positive results in recent decades, research is actively continued due to the growing economic and social burden of the disease. https://www.journals.vu.lt/neurologijos_seminarai/article/view/27849Alzheimer’s diseasedisease-modifying treatmentamyloidtau proteinclinical trials |
| spellingShingle | G. Pakulaitė V. Regelskytė E. Audronytė J. Kuzmickienė G. Kaubrys In search of Alzheimer’s disease treatment methods: trends of clinical trials Neurologijos seminarai Alzheimer’s disease disease-modifying treatment amyloid tau protein clinical trials |
| title | In search of Alzheimer’s disease treatment methods: trends of clinical trials |
| title_full | In search of Alzheimer’s disease treatment methods: trends of clinical trials |
| title_fullStr | In search of Alzheimer’s disease treatment methods: trends of clinical trials |
| title_full_unstemmed | In search of Alzheimer’s disease treatment methods: trends of clinical trials |
| title_short | In search of Alzheimer’s disease treatment methods: trends of clinical trials |
| title_sort | in search of alzheimer s disease treatment methods trends of clinical trials |
| topic | Alzheimer’s disease disease-modifying treatment amyloid tau protein clinical trials |
| url | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27849 |
| work_keys_str_mv | AT gpakulaite insearchofalzheimersdiseasetreatmentmethodstrendsofclinicaltrials AT vregelskyte insearchofalzheimersdiseasetreatmentmethodstrendsofclinicaltrials AT eaudronyte insearchofalzheimersdiseasetreatmentmethodstrendsofclinicaltrials AT jkuzmickiene insearchofalzheimersdiseasetreatmentmethodstrendsofclinicaltrials AT gkaubrys insearchofalzheimersdiseasetreatmentmethodstrendsofclinicaltrials |