Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with 2019 Novel Coronavirus (SARS-CoV-2) Infection
We report three critically ill pediatric patients (aged 6–10 years), presenting with features of multisystem inflammatory syndrome in children (MIS-C) from April 4 to May 10, 2020, to a tertiary-care center in New Jersey, United States. All patients tested positive for severe acute respiratory syndr...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2020/8875987 |
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| author | Helen Kest Ashlesha Kaushik William DeBruin Mario Colletti David Goldberg |
| author_facet | Helen Kest Ashlesha Kaushik William DeBruin Mario Colletti David Goldberg |
| author_sort | Helen Kest |
| collection | DOAJ |
| description | We report three critically ill pediatric patients (aged 6–10 years), presenting with features of multisystem inflammatory syndrome in children (MIS-C) from April 4 to May 10, 2020, to a tertiary-care center in New Jersey, United States. All patients tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and were previously healthy. Clinical presentations were similar with fever, abdominal pain, gastrointestinal complaints, and/or rash. One patient had altered mental status with cerebrospinal fluid (CSF) findings consistent with aseptic meningitis. Laboratory values were remarkable for high levels of C-reactive protein, D-dimers, B-type natriuretic peptide (BNP), and troponin in all patients. All had low albumin levels. Evaluation for other infectious etiologies was negative. All of the patients were critically ill, requiring admission to the intensive care unit. All had circulatory shock and needed inotropes. Two patients had respiratory failure requiring advanced respiratory support and one had cardiac dysfunction. All patients received steroids, and two received intravenous immunoglobulin (IVIG). One patient received tocilizumab. None of the children died. MIS-C is a recently recognized pediatric illness spectrum in association with SARS-CoV-2 infection, and clinical characterization is essential for understanding disease mechanisms to inform clinical practice. |
| format | Article |
| id | doaj-art-5347486bc43340868a886f61b5026602 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-5347486bc43340868a886f61b50266022025-02-03T05:53:54ZengWileyCase Reports in Pediatrics2090-68032090-68112020-01-01202010.1155/2020/88759878875987Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with 2019 Novel Coronavirus (SARS-CoV-2) InfectionHelen Kest0Ashlesha Kaushik1William DeBruin2Mario Colletti3David Goldberg4Pediatric Infectious Disease, Department of Pediatrics, St. Joseph’s Children’s Hospital, Paterson, NJ 07503, USAPediatric Infectious Diseases, Unity Point Health, University of Iowa, Carver College of Medicine, 2720 Stone Park Blvd, Sioux City, IA 51104, USAPediatric Intensive Care Unit, Department of Pediatrics, St. Joseph's Children's Hospital, Paterson, NJ 07503, USAPediatric Intensive Care Unit, Department of Pediatrics, St. Joseph's Children's Hospital, Paterson, NJ 07503, USAPediatric Infectious Disease, Department of Pediatrics, St. Joseph’s Children’s Hospital, Paterson, NJ 07503, USAWe report three critically ill pediatric patients (aged 6–10 years), presenting with features of multisystem inflammatory syndrome in children (MIS-C) from April 4 to May 10, 2020, to a tertiary-care center in New Jersey, United States. All patients tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and were previously healthy. Clinical presentations were similar with fever, abdominal pain, gastrointestinal complaints, and/or rash. One patient had altered mental status with cerebrospinal fluid (CSF) findings consistent with aseptic meningitis. Laboratory values were remarkable for high levels of C-reactive protein, D-dimers, B-type natriuretic peptide (BNP), and troponin in all patients. All had low albumin levels. Evaluation for other infectious etiologies was negative. All of the patients were critically ill, requiring admission to the intensive care unit. All had circulatory shock and needed inotropes. Two patients had respiratory failure requiring advanced respiratory support and one had cardiac dysfunction. All patients received steroids, and two received intravenous immunoglobulin (IVIG). One patient received tocilizumab. None of the children died. MIS-C is a recently recognized pediatric illness spectrum in association with SARS-CoV-2 infection, and clinical characterization is essential for understanding disease mechanisms to inform clinical practice.http://dx.doi.org/10.1155/2020/8875987 |
| spellingShingle | Helen Kest Ashlesha Kaushik William DeBruin Mario Colletti David Goldberg Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with 2019 Novel Coronavirus (SARS-CoV-2) Infection Case Reports in Pediatrics |
| title | Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with 2019 Novel Coronavirus (SARS-CoV-2) Infection |
| title_full | Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with 2019 Novel Coronavirus (SARS-CoV-2) Infection |
| title_fullStr | Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with 2019 Novel Coronavirus (SARS-CoV-2) Infection |
| title_full_unstemmed | Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with 2019 Novel Coronavirus (SARS-CoV-2) Infection |
| title_short | Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with 2019 Novel Coronavirus (SARS-CoV-2) Infection |
| title_sort | multisystem inflammatory syndrome in children mis c associated with 2019 novel coronavirus sars cov 2 infection |
| url | http://dx.doi.org/10.1155/2020/8875987 |
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