Effects of Type 2 Diabetic Serum on Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells
Diabetic patients have an increased risk of osteoporosis-associated fractures. However, the results of most studies of the effects of diabetes on bone mass in patients with type 2 diabetes (T2DM) have been contradictory. To clarify these conflicting findings, we investigated the effects of diabetic...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5765478 |
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| author | Xiangqun Deng Min Xu Moyu Shen Jinluo Cheng |
| author_facet | Xiangqun Deng Min Xu Moyu Shen Jinluo Cheng |
| author_sort | Xiangqun Deng |
| collection | DOAJ |
| description | Diabetic patients have an increased risk of osteoporosis-associated fractures. However, the results of most studies of the effects of diabetes on bone mass in patients with type 2 diabetes (T2DM) have been contradictory. To clarify these conflicting findings, we investigated the effects of diabetic serum on the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs). We used human sera from subjects with different levels of glycemic control to culture the MSCs and induce osteogenic differentiation. The rate of MSC proliferation differed when MSCs were cultured with sera from diabetic subjects with different levels of hyperglycemia. Hyperglycemic sera promoted MSC proliferation to some extent, but all the diabetic sera inhibited the differentiation of MSCs to osteoblasts. The effects of type 2 diabetic sera on the proliferation and osteogenic differentiation of MSCs are closely related to glycemic control. Our data demonstrate the importance of stratifying the study population according to glycemic control in clinical research into diabetic osteoporosis. |
| format | Article |
| id | doaj-art-53376a07d19840229fc25aa75dc61a9f |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-53376a07d19840229fc25aa75dc61a9f2025-02-03T01:21:56ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/57654785765478Effects of Type 2 Diabetic Serum on Proliferation and Osteogenic Differentiation of Mesenchymal Stem CellsXiangqun Deng0Min Xu1Moyu Shen2Jinluo Cheng3Department of Endocrinology, Wuhan Third Hospital, Wuhan University, Wuhan 430062, ChinaDepartment of Endocrinology, Changzhou No. 2 People’s Hospital, Nanjing Medical University, Changzhou 213003, ChinaDepartment of Endocrinology, Changzhou No. 2 People’s Hospital, Nanjing Medical University, Changzhou 213003, ChinaDepartment of Endocrinology, Changzhou No. 2 People’s Hospital, Nanjing Medical University, Changzhou 213003, ChinaDiabetic patients have an increased risk of osteoporosis-associated fractures. However, the results of most studies of the effects of diabetes on bone mass in patients with type 2 diabetes (T2DM) have been contradictory. To clarify these conflicting findings, we investigated the effects of diabetic serum on the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs). We used human sera from subjects with different levels of glycemic control to culture the MSCs and induce osteogenic differentiation. The rate of MSC proliferation differed when MSCs were cultured with sera from diabetic subjects with different levels of hyperglycemia. Hyperglycemic sera promoted MSC proliferation to some extent, but all the diabetic sera inhibited the differentiation of MSCs to osteoblasts. The effects of type 2 diabetic sera on the proliferation and osteogenic differentiation of MSCs are closely related to glycemic control. Our data demonstrate the importance of stratifying the study population according to glycemic control in clinical research into diabetic osteoporosis.http://dx.doi.org/10.1155/2018/5765478 |
| spellingShingle | Xiangqun Deng Min Xu Moyu Shen Jinluo Cheng Effects of Type 2 Diabetic Serum on Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells Journal of Diabetes Research |
| title | Effects of Type 2 Diabetic Serum on Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells |
| title_full | Effects of Type 2 Diabetic Serum on Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells |
| title_fullStr | Effects of Type 2 Diabetic Serum on Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells |
| title_full_unstemmed | Effects of Type 2 Diabetic Serum on Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells |
| title_short | Effects of Type 2 Diabetic Serum on Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells |
| title_sort | effects of type 2 diabetic serum on proliferation and osteogenic differentiation of mesenchymal stem cells |
| url | http://dx.doi.org/10.1155/2018/5765478 |
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