Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury
Spinal cord injury (SCI) causes a high rate of morbidity and disability. The clinical features of SCI are divided into acute, subacute, and chronic phases according to its pathophysiological events. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/7513748 |
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| author | Jingying Zhou Xue Huo Benson O. A. Botchway Luyao Xu Xiaofang Meng Songou Zhang Xuehong Liu |
| author_facet | Jingying Zhou Xue Huo Benson O. A. Botchway Luyao Xu Xiaofang Meng Songou Zhang Xuehong Liu |
| author_sort | Jingying Zhou |
| collection | DOAJ |
| description | Spinal cord injury (SCI) causes a high rate of morbidity and disability. The clinical features of SCI are divided into acute, subacute, and chronic phases according to its pathophysiological events. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and inflammation in the acute phase and neuroregeneration in the subacute/chronic phases at different times. Resveratrol has the potential of regulating cell growth, proliferation, metabolism, and angiogenesis through the mTOR signaling pathway. Herein, we explicate the role of resveratrol in the repair of SCI through the inhibition of the mTOR signaling pathway. The inhibition of the mTOR pathway by resveratrol has the potential of serving as a neuronal restorative mechanism following SCI. |
| format | Article |
| id | doaj-art-5313af4f5525456f9488aeb06d492432 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-5313af4f5525456f9488aeb06d4924322025-02-03T01:27:40ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/75137487513748Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord InjuryJingying Zhou0Xue Huo1Benson O. A. Botchway2Luyao Xu3Xiaofang Meng4Songou Zhang5Xuehong Liu6Department of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, ChinaInstitute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, ChinaInstitute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, ChinaDepartment of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, ChinaDepartment of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, ChinaDepartment of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, ChinaSpinal cord injury (SCI) causes a high rate of morbidity and disability. The clinical features of SCI are divided into acute, subacute, and chronic phases according to its pathophysiological events. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and inflammation in the acute phase and neuroregeneration in the subacute/chronic phases at different times. Resveratrol has the potential of regulating cell growth, proliferation, metabolism, and angiogenesis through the mTOR signaling pathway. Herein, we explicate the role of resveratrol in the repair of SCI through the inhibition of the mTOR signaling pathway. The inhibition of the mTOR pathway by resveratrol has the potential of serving as a neuronal restorative mechanism following SCI.http://dx.doi.org/10.1155/2018/7513748 |
| spellingShingle | Jingying Zhou Xue Huo Benson O. A. Botchway Luyao Xu Xiaofang Meng Songou Zhang Xuehong Liu Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury Neural Plasticity |
| title | Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury |
| title_full | Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury |
| title_fullStr | Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury |
| title_full_unstemmed | Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury |
| title_short | Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury |
| title_sort | beneficial effects of resveratrol mediated inhibition of the mtor pathway in spinal cord injury |
| url | http://dx.doi.org/10.1155/2018/7513748 |
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