The Role of the IL-20 Subfamily in Glaucoma
Glaucoma is a common disease that leads to loss of peripheral vision and, if left untreated, ultimately to blindness. While the exact cause(s) of glaucoma is still unknown, two leading risk factors are age and elevated intraocular pressure. Several studies suggest a possible link between glaucoma an...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/4083735 |
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| _version_ | 1832548459176001536 |
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| author | Mary K. Wirtz Kate E. Keller |
| author_facet | Mary K. Wirtz Kate E. Keller |
| author_sort | Mary K. Wirtz |
| collection | DOAJ |
| description | Glaucoma is a common disease that leads to loss of peripheral vision and, if left untreated, ultimately to blindness. While the exact cause(s) of glaucoma is still unknown, two leading risk factors are age and elevated intraocular pressure. Several studies suggest a possible link between glaucoma and inflammation in humans and animal models. In particular, our lab recently identified a T104M mutation in IL-20 receptor-B (IL-20RB) in primary open angle glaucoma patients from a large pedigree. Several of the interleukin- (IL-) 20 family of cytokines and receptors are expressed in ocular tissues including the trabecular meshwork, optic nerve head, and retinal ganglion cells. The DBA/2J mouse develops high intraocular pressures with age and has characteristic optic nerve defects that make it a useful glaucoma model. IL-24 expression is significantly upregulated in the retina of these mice, while IL-20RA expression in the optic nerve is downregulated following pressure-induced damage. The identification of a mutation in the IL-20RB gene in a glaucoma pedigree and changes in expression levels of IL-20 family members in the DBA/2J mouse suggest that disruption of normal IL-20 signaling in the eye may contribute to degenerative processes associated with glaucoma. |
| format | Article |
| id | doaj-art-53006339fcff400c8c30afa1956ee68b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-53006339fcff400c8c30afa1956ee68b2025-02-03T06:13:59ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/40837354083735The Role of the IL-20 Subfamily in GlaucomaMary K. Wirtz0Kate E. Keller1Casey Eye Institute, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, USACasey Eye Institute, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, USAGlaucoma is a common disease that leads to loss of peripheral vision and, if left untreated, ultimately to blindness. While the exact cause(s) of glaucoma is still unknown, two leading risk factors are age and elevated intraocular pressure. Several studies suggest a possible link between glaucoma and inflammation in humans and animal models. In particular, our lab recently identified a T104M mutation in IL-20 receptor-B (IL-20RB) in primary open angle glaucoma patients from a large pedigree. Several of the interleukin- (IL-) 20 family of cytokines and receptors are expressed in ocular tissues including the trabecular meshwork, optic nerve head, and retinal ganglion cells. The DBA/2J mouse develops high intraocular pressures with age and has characteristic optic nerve defects that make it a useful glaucoma model. IL-24 expression is significantly upregulated in the retina of these mice, while IL-20RA expression in the optic nerve is downregulated following pressure-induced damage. The identification of a mutation in the IL-20RB gene in a glaucoma pedigree and changes in expression levels of IL-20 family members in the DBA/2J mouse suggest that disruption of normal IL-20 signaling in the eye may contribute to degenerative processes associated with glaucoma.http://dx.doi.org/10.1155/2016/4083735 |
| spellingShingle | Mary K. Wirtz Kate E. Keller The Role of the IL-20 Subfamily in Glaucoma Mediators of Inflammation |
| title | The Role of the IL-20 Subfamily in Glaucoma |
| title_full | The Role of the IL-20 Subfamily in Glaucoma |
| title_fullStr | The Role of the IL-20 Subfamily in Glaucoma |
| title_full_unstemmed | The Role of the IL-20 Subfamily in Glaucoma |
| title_short | The Role of the IL-20 Subfamily in Glaucoma |
| title_sort | role of the il 20 subfamily in glaucoma |
| url | http://dx.doi.org/10.1155/2016/4083735 |
| work_keys_str_mv | AT marykwirtz theroleoftheil20subfamilyinglaucoma AT kateekeller theroleoftheil20subfamilyinglaucoma AT marykwirtz roleoftheil20subfamilyinglaucoma AT kateekeller roleoftheil20subfamilyinglaucoma |