Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo
This study is to explore the osteogenesis potential of the human periodontal ligament stem cells (hPDLSCs) induced by naringin in vitro and in vitro. The results confirmed that 1 μM naringin performs the best effect and a collection of bone-related genes (RUNX2, COL1A2, OPN, and OCN) had significant...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/758706 |
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| author | Lihua Yin Wenxiao Cheng Zishun Qin Hongdou Yu Zhanhai Yu Mei Zhong Kemo Sun Wei Zhang |
| author_facet | Lihua Yin Wenxiao Cheng Zishun Qin Hongdou Yu Zhanhai Yu Mei Zhong Kemo Sun Wei Zhang |
| author_sort | Lihua Yin |
| collection | DOAJ |
| description | This study is to explore the osteogenesis potential of the human periodontal ligament stem cells (hPDLSCs) induced by naringin in vitro and in vitro. The results confirmed that 1 μM naringin performs the best effect and a collection of bone-related genes (RUNX2, COL1A2, OPN, and OCN) had significantly higher expression levels compared to the control group. Furthermore, a typical trabecular structure was observed in vivo, surrounded by a large amount of osteoblasts. These results demonstrated that naringin, at a concentration of 1 μM, can efficiently promote the proliferation and differentiation of hPDLSCs both in vitro and in vivo. |
| format | Article |
| id | doaj-art-52ff93f596b440e69a913ba3d51623d2 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-52ff93f596b440e69a913ba3d51623d22025-02-03T01:32:47ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/758706758706Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In VivoLihua Yin0Wenxiao Cheng1Zishun Qin2Hongdou Yu3Zhanhai Yu4Mei Zhong5Kemo Sun6Wei Zhang7School of Life Sciences, Lanzhou University, Lanzhou, Gansu, ChinaSchool/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, ChinaSchool/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, ChinaSchool/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, ChinaSchool/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, ChinaSchool/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, ChinaSchool/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, ChinaShanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, No. 99 Haike Road, Pudong, Shanghai 201210, ChinaThis study is to explore the osteogenesis potential of the human periodontal ligament stem cells (hPDLSCs) induced by naringin in vitro and in vitro. The results confirmed that 1 μM naringin performs the best effect and a collection of bone-related genes (RUNX2, COL1A2, OPN, and OCN) had significantly higher expression levels compared to the control group. Furthermore, a typical trabecular structure was observed in vivo, surrounded by a large amount of osteoblasts. These results demonstrated that naringin, at a concentration of 1 μM, can efficiently promote the proliferation and differentiation of hPDLSCs both in vitro and in vivo.http://dx.doi.org/10.1155/2015/758706 |
| spellingShingle | Lihua Yin Wenxiao Cheng Zishun Qin Hongdou Yu Zhanhai Yu Mei Zhong Kemo Sun Wei Zhang Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo Stem Cells International |
| title | Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo |
| title_full | Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo |
| title_fullStr | Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo |
| title_full_unstemmed | Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo |
| title_short | Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo |
| title_sort | effects of naringin on proliferation and osteogenic differentiation of human periodontal ligament stem cells in vitro and in vivo |
| url | http://dx.doi.org/10.1155/2015/758706 |
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