A case–control study on vitamin D receptor gene polymorphisms in patients with Parkinson’s disease in Bangladesh
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder with a multifactorial etiology. This study aimed to investigate the association between vitamin D receptor (VDR) gene polymorphisms (ApaI, BsmI, FokI and TaqI) and the risk of PD in a Bangladeshi population. A case-control study was c...
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-96195-0 |
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| author | Narayan Chandra Kundu Anindya Kundu Md. Ibrahim Khalil K. M. Nazmul Islam Joy Moushumi Sen Zahid Hasan Md. Sahabuddin Md. Abdur Rafi Mohammad Jahid Hasan |
| author_facet | Narayan Chandra Kundu Anindya Kundu Md. Ibrahim Khalil K. M. Nazmul Islam Joy Moushumi Sen Zahid Hasan Md. Sahabuddin Md. Abdur Rafi Mohammad Jahid Hasan |
| author_sort | Narayan Chandra Kundu |
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| description | Abstract Parkinson’s disease (PD) is a neurodegenerative disorder with a multifactorial etiology. This study aimed to investigate the association between vitamin D receptor (VDR) gene polymorphisms (ApaI, BsmI, FokI and TaqI) and the risk of PD in a Bangladeshi population. A case-control study was conducted with 100 PD patients and 100 age- and sex-matched healthy controls. Serum vitamin D levels were measured using a chemiluminescent immunoassay, and VDR gene polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Genetic models (allele, dominant, recessive and additive models) were used to assess the association between each polymorphism and PD risk. The mean age of the patients with PD was 63 years, with 65% being male, while the control group had a mean age of 54.5 years and 60% were male. In genetic models, the T allele of the ApaI gene demonstrated a significant association with PD (OR 1.92, 95% CI 1.20–3.13, p-value 0.007). This significant association persisted across both recessive and additive models (for recessive model: OR 2.17, 95% CI 1.10–4.55, p-value 0.027 and for additive model: OR 2.78, 95% CI 1.22–6.67, p-value 0.015). Similarly, the T allele of the FokI gene was found to be significantly associated with PD (OR 2.27, 95% CI 1.43–3.57, p-value 0.001). This association was also evident in both dominant and additive models (for dominant model: OR 2.56, 95% CI 1.45–4.55, p-value 0.001 and for additive model: OR 3.03, 95% CI 1.67–5.56, p-value 0.001). Conversely, no significant associations were observed for the genetic polymorphisms of the BsmI and TaqI genes across any of the genetic models examined. The findings suggest that specific VDR gene polymorphisms, particularly ApaI and FokI, are significantly associated with the risk of PD in the Bangladeshi population. |
| format | Article |
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| spelling | doaj-art-52f7bd74ecf0441f83bc47f5524d30102025-08-20T02:17:01ZengNature PortfolioScientific Reports2045-23222025-04-011511910.1038/s41598-025-96195-0A case–control study on vitamin D receptor gene polymorphisms in patients with Parkinson’s disease in BangladeshNarayan Chandra Kundu0Anindya Kundu1Md. Ibrahim Khalil2K. M. Nazmul Islam Joy3Moushumi Sen4Zahid Hasan5Md. Sahabuddin6Md. Abdur Rafi7Mohammad Jahid Hasan8Department of Neurology, Shaheed Suhrawardy Medical CollegeUniversity of Western AustraliaDepartment of Neurology, Shaheed Suhrawardy Medical CollegeDepartment of Neurology, Shaheed Suhrawardy Medical CollegeDepartment of Biochemistry, Anwer Khan Modern Medical CollegeBangladesh University of Health ScienceBangladesh Specialized HospitalPi Research & Development CenterTropical Disease and Health Research CenterAbstract Parkinson’s disease (PD) is a neurodegenerative disorder with a multifactorial etiology. This study aimed to investigate the association between vitamin D receptor (VDR) gene polymorphisms (ApaI, BsmI, FokI and TaqI) and the risk of PD in a Bangladeshi population. A case-control study was conducted with 100 PD patients and 100 age- and sex-matched healthy controls. Serum vitamin D levels were measured using a chemiluminescent immunoassay, and VDR gene polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Genetic models (allele, dominant, recessive and additive models) were used to assess the association between each polymorphism and PD risk. The mean age of the patients with PD was 63 years, with 65% being male, while the control group had a mean age of 54.5 years and 60% were male. In genetic models, the T allele of the ApaI gene demonstrated a significant association with PD (OR 1.92, 95% CI 1.20–3.13, p-value 0.007). This significant association persisted across both recessive and additive models (for recessive model: OR 2.17, 95% CI 1.10–4.55, p-value 0.027 and for additive model: OR 2.78, 95% CI 1.22–6.67, p-value 0.015). Similarly, the T allele of the FokI gene was found to be significantly associated with PD (OR 2.27, 95% CI 1.43–3.57, p-value 0.001). This association was also evident in both dominant and additive models (for dominant model: OR 2.56, 95% CI 1.45–4.55, p-value 0.001 and for additive model: OR 3.03, 95% CI 1.67–5.56, p-value 0.001). Conversely, no significant associations were observed for the genetic polymorphisms of the BsmI and TaqI genes across any of the genetic models examined. The findings suggest that specific VDR gene polymorphisms, particularly ApaI and FokI, are significantly associated with the risk of PD in the Bangladeshi population.https://doi.org/10.1038/s41598-025-96195-0Parkinson’s diseaseVDR gene polymorphismsVitamin DNeurodegenerative disordersBangladesh |
| spellingShingle | Narayan Chandra Kundu Anindya Kundu Md. Ibrahim Khalil K. M. Nazmul Islam Joy Moushumi Sen Zahid Hasan Md. Sahabuddin Md. Abdur Rafi Mohammad Jahid Hasan A case–control study on vitamin D receptor gene polymorphisms in patients with Parkinson’s disease in Bangladesh Scientific Reports Parkinson’s disease VDR gene polymorphisms Vitamin D Neurodegenerative disorders Bangladesh |
| title | A case–control study on vitamin D receptor gene polymorphisms in patients with Parkinson’s disease in Bangladesh |
| title_full | A case–control study on vitamin D receptor gene polymorphisms in patients with Parkinson’s disease in Bangladesh |
| title_fullStr | A case–control study on vitamin D receptor gene polymorphisms in patients with Parkinson’s disease in Bangladesh |
| title_full_unstemmed | A case–control study on vitamin D receptor gene polymorphisms in patients with Parkinson’s disease in Bangladesh |
| title_short | A case–control study on vitamin D receptor gene polymorphisms in patients with Parkinson’s disease in Bangladesh |
| title_sort | case control study on vitamin d receptor gene polymorphisms in patients with parkinson s disease in bangladesh |
| topic | Parkinson’s disease VDR gene polymorphisms Vitamin D Neurodegenerative disorders Bangladesh |
| url | https://doi.org/10.1038/s41598-025-96195-0 |
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