Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome
Erectile dysfunction (ED), metabolic syndrome (MetS), and hypogonadism are closely related, often coexisting in the aging male. Obesity was shown to raise the risk of ED and hypogonadism, as well as other endocrinological disturbances with impact on erectile function. We selected 179 patients referr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/107869 |
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| author | Inês Campos Costa Hugo Nogueira Carvalho Luís Pacheco-Figueiredo Inês Tomada Nuno Tomada |
| author_facet | Inês Campos Costa Hugo Nogueira Carvalho Luís Pacheco-Figueiredo Inês Tomada Nuno Tomada |
| author_sort | Inês Campos Costa |
| collection | DOAJ |
| description | Erectile dysfunction (ED), metabolic syndrome (MetS), and hypogonadism are closely related, often coexisting in the aging male. Obesity was shown to raise the risk of ED and hypogonadism, as well as other endocrinological disturbances with impact on erectile function. We selected 179 patients referred for ED to our andrology unit, aiming to evaluate gonadotropins and estradiol interplay in context of ED, MetS, and hypogonadism. Patients were stratified into groups in accordance with the presence (or not) of MetS and/or hypogonadism. Noticeable differences in total testosterone (TT) and free testosterone (FT) levels were found between patients with and without MetS. Men with MetS evidenced lower TT circulating levels with an increasing number of MetS parameters, for which hypertriglyceridemia and waist circumference strongly contributed. Regarding the hypothalamic-pituitary-gonadal axis, patients with hypogonadism did not exhibit raised LH levels. Interestingly, among those with higher LH levels, estradiol values were also increased. Possible explanations for this unexpected profile of estradiol may be the age-related adiposity, other estrogen-raising pathways, or even unknown mechanisms. Estradiol is possibly a molecule with further interactions beyond the currently described. Our results further enlighten this still unclear multidisciplinary and complex subject, raising new investigational opportunities. |
| format | Article |
| id | doaj-art-52daf744f43c410db1c05ec5c3160608 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-52daf744f43c410db1c05ec5c31606082025-02-03T01:11:36ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/107869107869Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic SyndromeInês Campos Costa0Hugo Nogueira Carvalho1Luís Pacheco-Figueiredo2Inês Tomada3Nuno Tomada4Faculty of Medicine, Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, PortugalFaculty of Medicine, Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, PortugalDepartment of Urology, São João Central Hospital, Alameda Professor Hernâni Monteiro, 4200-319 Porto, PortugalDepartment of Experimental Biology, Faculty of Medicine, Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, PortugalFaculty of Medicine, Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, PortugalErectile dysfunction (ED), metabolic syndrome (MetS), and hypogonadism are closely related, often coexisting in the aging male. Obesity was shown to raise the risk of ED and hypogonadism, as well as other endocrinological disturbances with impact on erectile function. We selected 179 patients referred for ED to our andrology unit, aiming to evaluate gonadotropins and estradiol interplay in context of ED, MetS, and hypogonadism. Patients were stratified into groups in accordance with the presence (or not) of MetS and/or hypogonadism. Noticeable differences in total testosterone (TT) and free testosterone (FT) levels were found between patients with and without MetS. Men with MetS evidenced lower TT circulating levels with an increasing number of MetS parameters, for which hypertriglyceridemia and waist circumference strongly contributed. Regarding the hypothalamic-pituitary-gonadal axis, patients with hypogonadism did not exhibit raised LH levels. Interestingly, among those with higher LH levels, estradiol values were also increased. Possible explanations for this unexpected profile of estradiol may be the age-related adiposity, other estrogen-raising pathways, or even unknown mechanisms. Estradiol is possibly a molecule with further interactions beyond the currently described. Our results further enlighten this still unclear multidisciplinary and complex subject, raising new investigational opportunities.http://dx.doi.org/10.1155/2013/107869 |
| spellingShingle | Inês Campos Costa Hugo Nogueira Carvalho Luís Pacheco-Figueiredo Inês Tomada Nuno Tomada Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome International Journal of Endocrinology |
| title | Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome |
| title_full | Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome |
| title_fullStr | Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome |
| title_full_unstemmed | Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome |
| title_short | Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome |
| title_sort | hormonal modulation in aging patients with erectile dysfunction and metabolic syndrome |
| url | http://dx.doi.org/10.1155/2013/107869 |
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