The Risk Factors for Diabetic Retinopathy in a Chinese Population: A Cross-Sectional Study
Aims. Epidemiological data on diabetic retinopathy (DR) in Chinese population is still rather scarce, and risk factors for diabetic retinopathy are inconsistent because of study designs, grading standards, and population samples. Materials and Methods. This hospital-based retrospective study include...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/5340453 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555237860179968 |
|---|---|
| author | Qingmin Sun Yali Jing Bingjie Zhang Tianwei Gu Ran Meng Jie Sun Dalong Zhu Yaping Wang |
| author_facet | Qingmin Sun Yali Jing Bingjie Zhang Tianwei Gu Ran Meng Jie Sun Dalong Zhu Yaping Wang |
| author_sort | Qingmin Sun |
| collection | DOAJ |
| description | Aims. Epidemiological data on diabetic retinopathy (DR) in Chinese population is still rather scarce, and risk factors for diabetic retinopathy are inconsistent because of study designs, grading standards, and population samples. Materials and Methods. This hospital-based retrospective study included 1052 type 2 diabetes patients. Diabetic retinopathy was diagnosed by nonmydriatic fundus photography and/or fundus examination apparatus. Logistic regression analysis was performed to evaluate the risk of diabetic retinopathy. Results. A total of 352 (33.5% prevalence) subjects were diagnosed with diabetic retinopathy based on our population. The patients in the DR group not only had significantly higher hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), urinary microalbumin-creatinine ratio (ACR), and systolic blood pressure but also had higher follicle-stimulating hormone (FSH), luteinizing hormone (LH), and sex hormone-binding globulin (SHBG) levels compared to those in the non-DR group. Moreover, we confirmed that diabetes duration and HbA1c are strongly associated with DR risk. We also found that serum LH was an independent risk factor in male diabetic retinopathy patients (OR=1.086, 95% CI 1.024–1.152), and the levels of LH were significantly associated with diabetic retinopathy prevalence (P=0.018). Conclusions. Our study strengthens the argument that diabetes duration and HbA1c are risk factors for patients with DR. Additionally; we firstly confirmed that serum LH was an independent risk factor in male diabetic retinopathy patients. |
| format | Article |
| id | doaj-art-52d55d076bac488b81ecf0f9c803e6e7 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-52d55d076bac488b81ecf0f9c803e6e72025-02-03T05:49:15ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/53404535340453The Risk Factors for Diabetic Retinopathy in a Chinese Population: A Cross-Sectional StudyQingmin Sun0Yali Jing1Bingjie Zhang2Tianwei Gu3Ran Meng4Jie Sun5Dalong Zhu6Yaping Wang7Department of Medical Genetics, Nanjing University School of Medicine, Nanjing 210093, ChinaDepartment of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No321 Zhongshan Road, Nanjing 210008, ChinaDepartment of Medical Genetics, Nanjing University School of Medicine, Nanjing 210093, ChinaAims. Epidemiological data on diabetic retinopathy (DR) in Chinese population is still rather scarce, and risk factors for diabetic retinopathy are inconsistent because of study designs, grading standards, and population samples. Materials and Methods. This hospital-based retrospective study included 1052 type 2 diabetes patients. Diabetic retinopathy was diagnosed by nonmydriatic fundus photography and/or fundus examination apparatus. Logistic regression analysis was performed to evaluate the risk of diabetic retinopathy. Results. A total of 352 (33.5% prevalence) subjects were diagnosed with diabetic retinopathy based on our population. The patients in the DR group not only had significantly higher hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), urinary microalbumin-creatinine ratio (ACR), and systolic blood pressure but also had higher follicle-stimulating hormone (FSH), luteinizing hormone (LH), and sex hormone-binding globulin (SHBG) levels compared to those in the non-DR group. Moreover, we confirmed that diabetes duration and HbA1c are strongly associated with DR risk. We also found that serum LH was an independent risk factor in male diabetic retinopathy patients (OR=1.086, 95% CI 1.024–1.152), and the levels of LH were significantly associated with diabetic retinopathy prevalence (P=0.018). Conclusions. Our study strengthens the argument that diabetes duration and HbA1c are risk factors for patients with DR. Additionally; we firstly confirmed that serum LH was an independent risk factor in male diabetic retinopathy patients.http://dx.doi.org/10.1155/2021/5340453 |
| spellingShingle | Qingmin Sun Yali Jing Bingjie Zhang Tianwei Gu Ran Meng Jie Sun Dalong Zhu Yaping Wang The Risk Factors for Diabetic Retinopathy in a Chinese Population: A Cross-Sectional Study Journal of Diabetes Research |
| title | The Risk Factors for Diabetic Retinopathy in a Chinese Population: A Cross-Sectional Study |
| title_full | The Risk Factors for Diabetic Retinopathy in a Chinese Population: A Cross-Sectional Study |
| title_fullStr | The Risk Factors for Diabetic Retinopathy in a Chinese Population: A Cross-Sectional Study |
| title_full_unstemmed | The Risk Factors for Diabetic Retinopathy in a Chinese Population: A Cross-Sectional Study |
| title_short | The Risk Factors for Diabetic Retinopathy in a Chinese Population: A Cross-Sectional Study |
| title_sort | risk factors for diabetic retinopathy in a chinese population a cross sectional study |
| url | http://dx.doi.org/10.1155/2021/5340453 |
| work_keys_str_mv | AT qingminsun theriskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT yalijing theriskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT bingjiezhang theriskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT tianweigu theriskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT ranmeng theriskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT jiesun theriskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT dalongzhu theriskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT yapingwang theriskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT qingminsun riskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT yalijing riskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT bingjiezhang riskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT tianweigu riskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT ranmeng riskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT jiesun riskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT dalongzhu riskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy AT yapingwang riskfactorsfordiabeticretinopathyinachinesepopulationacrosssectionalstudy |