Development of perivascular astrocyte processes
Astrocytes are key glial cells in the brain that form specialized contacts with the vascular system. Together, these interactions constitute the gliovascular unit (GVU), which is an interface between the brain and the blood crucial for the maintenance of the structure and functions of the brain. The...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1585340/full |
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| author | Martine Cohen-Salmon Naomie Guille Anne-Cécile Boulay |
| author_facet | Martine Cohen-Salmon Naomie Guille Anne-Cécile Boulay |
| author_sort | Martine Cohen-Salmon |
| collection | DOAJ |
| description | Astrocytes are key glial cells in the brain that form specialized contacts with the vascular system. Together, these interactions constitute the gliovascular unit (GVU), which is an interface between the brain and the blood crucial for the maintenance of the structure and functions of the brain. The development of the GVU is a complex process involving multiple steps and intricate interactions among astrocytes, neural cells, and vascular components. In this review, we aim to summarize the current understanding of the development of the astrocyte–vascular interface and to explore how early developmental alterations in this system may contribute to brain dysfunction. |
| format | Article |
| id | doaj-art-52cd4fa86fcb4a689ecb56bfe2dee9b7 |
| institution | DOAJ |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-52cd4fa86fcb4a689ecb56bfe2dee9b72025-08-20T03:16:10ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-07-011910.3389/fnins.2025.15853401585340Development of perivascular astrocyte processesMartine Cohen-SalmonNaomie GuilleAnne-Cécile BoulayAstrocytes are key glial cells in the brain that form specialized contacts with the vascular system. Together, these interactions constitute the gliovascular unit (GVU), which is an interface between the brain and the blood crucial for the maintenance of the structure and functions of the brain. The development of the GVU is a complex process involving multiple steps and intricate interactions among astrocytes, neural cells, and vascular components. In this review, we aim to summarize the current understanding of the development of the astrocyte–vascular interface and to explore how early developmental alterations in this system may contribute to brain dysfunction.https://www.frontiersin.org/articles/10.3389/fnins.2025.1585340/fullastrocytesblood vesselsperivascular astrocyte processesendfeetgliovascular unitneurovascular unit |
| spellingShingle | Martine Cohen-Salmon Naomie Guille Anne-Cécile Boulay Development of perivascular astrocyte processes Frontiers in Neuroscience astrocytes blood vessels perivascular astrocyte processes endfeet gliovascular unit neurovascular unit |
| title | Development of perivascular astrocyte processes |
| title_full | Development of perivascular astrocyte processes |
| title_fullStr | Development of perivascular astrocyte processes |
| title_full_unstemmed | Development of perivascular astrocyte processes |
| title_short | Development of perivascular astrocyte processes |
| title_sort | development of perivascular astrocyte processes |
| topic | astrocytes blood vessels perivascular astrocyte processes endfeet gliovascular unit neurovascular unit |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1585340/full |
| work_keys_str_mv | AT martinecohensalmon developmentofperivascularastrocyteprocesses AT naomieguille developmentofperivascularastrocyteprocesses AT annececileboulay developmentofperivascularastrocyteprocesses |