Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis
Background. Depression after stroke may have great burden on the likelihood of functional recovery and long-term outcomes. Objective. To estimate the association between depression after stroke and subsequent mortality. Methods. A systematic search of articles using PubMed and Web of Science databas...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2013/862978 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555531845238784 |
|---|---|
| author | Francesco Bartoli Nicoletta Lillia Annamaria Lax Cristina Crocamo Vittorio Mantero Giuseppe Carrà Elio Agostoni Massimo Clerici |
| author_facet | Francesco Bartoli Nicoletta Lillia Annamaria Lax Cristina Crocamo Vittorio Mantero Giuseppe Carrà Elio Agostoni Massimo Clerici |
| author_sort | Francesco Bartoli |
| collection | DOAJ |
| description | Background. Depression after stroke may have great burden on the likelihood of functional recovery and long-term outcomes. Objective. To estimate the association between depression after stroke and subsequent mortality. Methods. A systematic search of articles using PubMed and Web of Science databases was performed. Odds ratios (ORs) and hazard ratios (HRs) were used as association measures for pooled analyses, based on random-effects models. Results. Thirteen studies, involving 59,598 subjects suffering from stroke (6,052 with and 53,546 without depression), had data suitable for meta-analysis. The pooled OR for mortality at followup in people suffering from depression after stroke was 1.22 (1.02–1.47). Subgroups analyses highlighted that only studies with medium-term followup (2–5 years) showed a statistically significant association between depression and risk of death. Four studies had data suitable for further analysis of pooled HR. The meta-analysis revealed a HR for mortality of 1.52 (1.02–2.26) among people with depression after stroke. Conclusions. Despite some limitations, this paper confirms the potential role of depression on post stroke mortality. The relationship between depression and mortality after stroke seems to be related to the followup duration. Further research is needed to clarify the nature of the association between depression after stroke and mortality. |
| format | Article |
| id | doaj-art-52cc4258457f466aaf369cc0dbc3f022 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-52cc4258457f466aaf369cc0dbc3f0222025-02-03T05:47:53ZengWileyStroke Research and Treatment2090-81052042-00562013-01-01201310.1155/2013/862978862978Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-AnalysisFrancesco Bartoli0Nicoletta Lillia1Annamaria Lax2Cristina Crocamo3Vittorio Mantero4Giuseppe Carrà5Elio Agostoni6Massimo Clerici7Department of Surgery and Interdisciplinary Medicine, University of Milano-Bicocca, 20900 Monza, ItalyStroke Unit, Neurology Department, Azienda Ospedaliera Niguarda Cà Granda, 20162 Milan, ItalyDepartment of Surgery and Interdisciplinary Medicine, University of Milano-Bicocca, 20900 Monza, ItalyDepartment of Mental Health, Azienda Ospedaliera San Gerardo, 20900 Monza, ItalyStroke Unit, Neurology Department, Azienda Ospedaliera Niguarda Cà Granda, 20162 Milan, ItalyDepartment of Mental Health, Azienda Ospedaliera San Gerardo, 20900 Monza, ItalyStroke Unit, Neurology Department, Azienda Ospedaliera Niguarda Cà Granda, 20162 Milan, ItalyDepartment of Surgery and Interdisciplinary Medicine, University of Milano-Bicocca, 20900 Monza, ItalyBackground. Depression after stroke may have great burden on the likelihood of functional recovery and long-term outcomes. Objective. To estimate the association between depression after stroke and subsequent mortality. Methods. A systematic search of articles using PubMed and Web of Science databases was performed. Odds ratios (ORs) and hazard ratios (HRs) were used as association measures for pooled analyses, based on random-effects models. Results. Thirteen studies, involving 59,598 subjects suffering from stroke (6,052 with and 53,546 without depression), had data suitable for meta-analysis. The pooled OR for mortality at followup in people suffering from depression after stroke was 1.22 (1.02–1.47). Subgroups analyses highlighted that only studies with medium-term followup (2–5 years) showed a statistically significant association between depression and risk of death. Four studies had data suitable for further analysis of pooled HR. The meta-analysis revealed a HR for mortality of 1.52 (1.02–2.26) among people with depression after stroke. Conclusions. Despite some limitations, this paper confirms the potential role of depression on post stroke mortality. The relationship between depression and mortality after stroke seems to be related to the followup duration. Further research is needed to clarify the nature of the association between depression after stroke and mortality.http://dx.doi.org/10.1155/2013/862978 |
| spellingShingle | Francesco Bartoli Nicoletta Lillia Annamaria Lax Cristina Crocamo Vittorio Mantero Giuseppe Carrà Elio Agostoni Massimo Clerici Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis Stroke Research and Treatment |
| title | Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis |
| title_full | Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis |
| title_fullStr | Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis |
| title_short | Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis |
| title_sort | depression after stroke and risk of mortality a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2013/862978 |
| work_keys_str_mv | AT francescobartoli depressionafterstrokeandriskofmortalityasystematicreviewandmetaanalysis AT nicolettalillia depressionafterstrokeandriskofmortalityasystematicreviewandmetaanalysis AT annamarialax depressionafterstrokeandriskofmortalityasystematicreviewandmetaanalysis AT cristinacrocamo depressionafterstrokeandriskofmortalityasystematicreviewandmetaanalysis AT vittoriomantero depressionafterstrokeandriskofmortalityasystematicreviewandmetaanalysis AT giuseppecarra depressionafterstrokeandriskofmortalityasystematicreviewandmetaanalysis AT elioagostoni depressionafterstrokeandriskofmortalityasystematicreviewandmetaanalysis AT massimoclerici depressionafterstrokeandriskofmortalityasystematicreviewandmetaanalysis |