Balancing Inflammation: The Link between Th17 and Regulatory T Cells
CD4+ T cell compartments in mouse and man are composed of multiple distinct subsets each possessing unique phenotypic and functional characteristics. IL-17-producing CD4+ T cells (Th17 cells) represent a distinct subset of the CD4+ T cell lineage. Recent evidence suggests that Th17 cells carry out e...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/6309219 |
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| _version_ | 1832548458484989952 |
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| author | Maggie L. Diller Ragini R. Kudchadkar Keith A. Delman David H. Lawson Mandy L. Ford |
| author_facet | Maggie L. Diller Ragini R. Kudchadkar Keith A. Delman David H. Lawson Mandy L. Ford |
| author_sort | Maggie L. Diller |
| collection | DOAJ |
| description | CD4+ T cell compartments in mouse and man are composed of multiple distinct subsets each possessing unique phenotypic and functional characteristics. IL-17-producing CD4+ T cells (Th17 cells) represent a distinct subset of the CD4+ T cell lineage. Recent evidence suggests that Th17 cells carry out effector functions similar to cytotoxic CD8+ T cells and play an important role in the clearance of extracellular pathogens and fungi. Th17 cell differentiation and function are closely related to the development and function of regulatory T cells (TREG). The balance between these two cell populations is essential for immune homeostasis and dysregulation of this balance has been implicated in a variety of inflammatory conditions including autoimmunity, allograft rejection, and tumorigenesis. Emerging evidence reports a significant amount of plasticity between the Th17 and regulatory T cell compartments, and the mechanisms by which these cells communicate and influence each other are just beginning to be understood. In this review, we highlight recent findings detailing the mechanisms driving Th17 and TREG plasticity and discuss the biologic consequences of their unique relationship. |
| format | Article |
| id | doaj-art-52c4f3bb18194f1c854fee64384e13d9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-52c4f3bb18194f1c854fee64384e13d92025-02-03T06:13:59ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/63092196309219Balancing Inflammation: The Link between Th17 and Regulatory T CellsMaggie L. Diller0Ragini R. Kudchadkar1Keith A. Delman2David H. Lawson3Mandy L. Ford4Department of Surgery of Emory University, 1364 Clifton Road, Atlanta, GA 30322, USADepartment of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, 1365 Clifton Road No. C, Atlanta, GA 30322, USADepartment of Surgical Oncology, Winship Cancer Institute of Emory University, 1365 Clifton Road No. C, Atlanta, GA 30322, USADepartment of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, 1365 Clifton Road No. C, Atlanta, GA 30322, USAEmory Transplant Center of Emory University, 5105 Woodruff Memorial Research Building, 101 Woodruff Circle, Atlanta, GA 30322, USACD4+ T cell compartments in mouse and man are composed of multiple distinct subsets each possessing unique phenotypic and functional characteristics. IL-17-producing CD4+ T cells (Th17 cells) represent a distinct subset of the CD4+ T cell lineage. Recent evidence suggests that Th17 cells carry out effector functions similar to cytotoxic CD8+ T cells and play an important role in the clearance of extracellular pathogens and fungi. Th17 cell differentiation and function are closely related to the development and function of regulatory T cells (TREG). The balance between these two cell populations is essential for immune homeostasis and dysregulation of this balance has been implicated in a variety of inflammatory conditions including autoimmunity, allograft rejection, and tumorigenesis. Emerging evidence reports a significant amount of plasticity between the Th17 and regulatory T cell compartments, and the mechanisms by which these cells communicate and influence each other are just beginning to be understood. In this review, we highlight recent findings detailing the mechanisms driving Th17 and TREG plasticity and discuss the biologic consequences of their unique relationship.http://dx.doi.org/10.1155/2016/6309219 |
| spellingShingle | Maggie L. Diller Ragini R. Kudchadkar Keith A. Delman David H. Lawson Mandy L. Ford Balancing Inflammation: The Link between Th17 and Regulatory T Cells Mediators of Inflammation |
| title | Balancing Inflammation: The Link between Th17 and Regulatory T Cells |
| title_full | Balancing Inflammation: The Link between Th17 and Regulatory T Cells |
| title_fullStr | Balancing Inflammation: The Link between Th17 and Regulatory T Cells |
| title_full_unstemmed | Balancing Inflammation: The Link between Th17 and Regulatory T Cells |
| title_short | Balancing Inflammation: The Link between Th17 and Regulatory T Cells |
| title_sort | balancing inflammation the link between th17 and regulatory t cells |
| url | http://dx.doi.org/10.1155/2016/6309219 |
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