Clinical profile of adults and children with reactive arthritis in India – A cohort study
Background: An evolving clinicodemographic spectrum is reported in reactive arthritis (reA) with the changing microbial profile in recent times. Moreover, understanding of chronic disease patterns is limited due to widespread beliefs of a self-limiting nature. We thus assessed the clinical profile o...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-01-01
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| Series: | Indian Journal of Rheumatology |
| Subjects: | |
| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=4;spage=304;epage=309;aulast=Thomas |
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| Summary: | Background: An evolving clinicodemographic spectrum is reported in reactive arthritis (reA) with the changing microbial profile in recent times. Moreover, understanding of chronic disease patterns is limited due to widespread beliefs of a self-limiting nature. We thus assessed the clinical profile of a cohort of acute reA and compare them with chronic reA.
Methods: A hospital-based study of prevalent triggers and demographic features, articular and extra-articular manifestations, and radiological findings was undertaken in children and adults with reA at a tertiary care center in northern India.
Results: Sixty-eight cases (8 juvenile, 41 acute, and 27 chronic) of age 26 years (18–34, M:F 5.8:1) and disease duration 36 (19–60) days were enrolled. Enteritis was the most common preceding trigger (37, 54%), followed by genitourinary infection (25, 36%), irrespective of gender. The clinical spectrum mirrored previous descriptions, with arthritis in most (95%), enthesitis in 33%, and conjunctivitis and circinate balanitis being the most common extra-articular features (8% each). Numerous cases (n = 7) did not fulfill the Braun's criteria at the current visit though a high representation of sacroiliitis was noted (20%, 12%) in acute as well as chronic reA. Enthesitis was more common in the acute reA (P = 0.018) and mucocutaneous features occurred only at inception. Otherwise, the clinical profile was similar in cases triggered by urethritis and enteritis, and in children as compared with adults.
Conclusion: These observations of varied spectrum of reA assume larger importance in light of the emerging concept of a unified clinic-pathologic spectrum of spondyloarthritis. |
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| ISSN: | 0973-3698 0973-3701 |