Association of Voltage-Gated Potassium Channel Polymorphisms with the Risk and Prognosis of Epilepsy in the Saudi Population: A Case–Control Study
<i>Background and Objectives</i>: Epilepsy, known as an unprovoked seizure, arises from the human brain. Genetics plays a fundamental role in the development and progression of the disorder. This study aimed to investigate the influence of voltage-gated K<sup>+</sup> channels...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/61/3/396 |
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| Summary: | <i>Background and Objectives</i>: Epilepsy, known as an unprovoked seizure, arises from the human brain. Genetics plays a fundamental role in the development and progression of the disorder. This study aimed to investigate the influence of voltage-gated K<sup>+</sup> channels on the risk of epilepsy. <i>Materials and Methods</i>: Several genetic variants were examined using PCR sequencing. This case–control study was conducted on 296 individuals who were diagnosed with epilepsy, in addition to 293 healthy participants. <i>Results</i>: This study revealed that within <i>KCNAB1</i>, both rs3755631 and rs4679773 are correlated with epilepsy, and the <i>p</i>-values = 0.04 for both allelic associations. In addition, regarding the <i>KCNJ10</i> gene, we found that rs2820585, rs946420, rs1186679, rs61822012, and rs1186685 were significantly correlated with epilepsy risk (<i>p</i>-values = 0.034, 0.045, 0.021, 0.048, and 0.018), respectively. <i>Conclusions</i>: From the current study, we conclude that voltage-gated potassium channels can impact epilepsy risk and can also interfere with the prognosis of epilepsy. |
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| ISSN: | 1010-660X 1648-9144 |