Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers
Despite variability, the majority of HIV-1-infected individuals progress to AIDS characterized by high viral load and massive CD4+ T-cell depletion. However, there is a subset of HIV-1-positive individuals that does not progress and spontaneously maintains an undetectable viral load. This infrequent...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/869505 |
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| author | Jean-Philippe Herbeuval Nikaïa Smith Jacques Thèze |
| author_facet | Jean-Philippe Herbeuval Nikaïa Smith Jacques Thèze |
| author_sort | Jean-Philippe Herbeuval |
| collection | DOAJ |
| description | Despite variability, the majority of HIV-1-infected individuals progress to AIDS characterized by high viral load and massive CD4+ T-cell depletion. However, there is a subset of HIV-1-positive individuals that does not progress and spontaneously maintains an undetectable viral load. This infrequent patient population is defined as HIV-1 controllers (HIV controllers), and represents less than 1% of HIV-1-infected patients. HIV-1-specific CD4+ T cells and the pool of central memory CD4+ T cells are also preserved despite immune activation due to HIV-1 infection. The majority of HIV controllers are also defined by the absence of massive CD4+ T-cell depletion, even after 10 years of infection. However, the mechanisms involved in protection against HIV-1 disease progression have not been elucidated yet. Controllers represent a heterogeneous population; we describe in this paper some common characteristics concerning innate immune response and CD4+ T cells of HIV controllers. |
| format | Article |
| id | doaj-art-52b3fea8adde49ab8be15225862fb319 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-52b3fea8adde49ab8be15225862fb3192025-02-03T01:11:26ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/869505869505Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite ControllersJean-Philippe Herbeuval0Nikaïa Smith1Jacques Thèze2CNRS UMR 8147 and Hôpital Necker, Université Paris Descartes, 149-161 rue de Sèvres, 75015 Paris, FranceCNRS UMR 8601, Université Paris Descartes, 45 rue des Saint-Pères, 75006 Paris, FranceUnité d'Immunologie Humaine, Centre Medical Necker Pasteur, Institut Pasteur, 28 Rue du Docteur Roux, 75015 Paris, FranceDespite variability, the majority of HIV-1-infected individuals progress to AIDS characterized by high viral load and massive CD4+ T-cell depletion. However, there is a subset of HIV-1-positive individuals that does not progress and spontaneously maintains an undetectable viral load. This infrequent patient population is defined as HIV-1 controllers (HIV controllers), and represents less than 1% of HIV-1-infected patients. HIV-1-specific CD4+ T cells and the pool of central memory CD4+ T cells are also preserved despite immune activation due to HIV-1 infection. The majority of HIV controllers are also defined by the absence of massive CD4+ T-cell depletion, even after 10 years of infection. However, the mechanisms involved in protection against HIV-1 disease progression have not been elucidated yet. Controllers represent a heterogeneous population; we describe in this paper some common characteristics concerning innate immune response and CD4+ T cells of HIV controllers.http://dx.doi.org/10.1155/2012/869505 |
| spellingShingle | Jean-Philippe Herbeuval Nikaïa Smith Jacques Thèze Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers Clinical and Developmental Immunology |
| title | Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers |
| title_full | Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers |
| title_fullStr | Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers |
| title_full_unstemmed | Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers |
| title_short | Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers |
| title_sort | characteristics of plasmacytoid dendritic cell and cd4 t cell in hiv elite controllers |
| url | http://dx.doi.org/10.1155/2012/869505 |
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