Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation
Leukocytosis and thrombocytopenia occur during cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC). Elevated circulating concentrations of macrophage colony-stimulating factor (M-CSF) are reported during thrombocytopenia and leukopenia of different origins. We have assessed M-CSF conc...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1996-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935196000518 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566611988447232 |
|---|---|
| author | Y. Denizot P. Fixe E. Cornu N. Nathan |
| author_facet | Y. Denizot P. Fixe E. Cornu N. Nathan |
| author_sort | Y. Denizot |
| collection | DOAJ |
| description | Leukocytosis and thrombocytopenia occur during cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC). Elevated circulating concentrations of macrophage colony-stimulating factor (M-CSF) are reported during thrombocytopenia and leukopenia of different origins. We have assessed M-CSF concentrations in 40 patients undergoing CPB with ECC. Plasma M-CSF concentrations were stable during ECC and increased at the 6th (7.3 ± 0.7 IU/μg protein) and 24th (8.6 ± 0.8 IU/μg protein) postoperative hour compared with pre-ECC values (4.9 ± 0.5 IU/μg protein). A deep thrombocytopenia was found during ECC and until the 24th postoperative hour. A drop of leukocyte counts was found during ECC followed by an increase after ECC weaning. While no correlation was found between M-CSF concentrations and the leukocyte counts, M-CSF values were positively correlated with platelet counts only before and during ECC. Thus, M-CSF is not implicated in the thrombocytopenia and the leukopenia generated during CPB with ECC. However the elevated levels of M-CSFa few hours after the end of ECC might play a role in the inflammatory process often observed after CPB. |
| format | Article |
| id | doaj-art-52ae69ae93644f17ba8656587107a1ec |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1996-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-52ae69ae93644f17ba8656587107a1ec2025-02-03T01:03:39ZengWileyMediators of Inflammation0962-93511466-18611996-01-015535836110.1155/S0962935196000518Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulationY. Denizot0P. Fixe1E. Cornu2N. Nathan3Department of Anaesthesia, CHRU Dupuytren, 2 Avenue Martin Luther King, Limoges 87042, FranceDepartment of Anaesthesia, CHRU Dupuytren, 2 Avenue Martin Luther King, Limoges 87042, FranceDepartment of Cardiovascular Surgery, CHRU Dupuytren, 2 Avenue Martin Luther King, Limoges 87042, FranceDepartment of Anaesthesia, CHRU Dupuytren, 2 Avenue Martin Luther King, Limoges 87042, FranceLeukocytosis and thrombocytopenia occur during cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC). Elevated circulating concentrations of macrophage colony-stimulating factor (M-CSF) are reported during thrombocytopenia and leukopenia of different origins. We have assessed M-CSF concentrations in 40 patients undergoing CPB with ECC. Plasma M-CSF concentrations were stable during ECC and increased at the 6th (7.3 ± 0.7 IU/μg protein) and 24th (8.6 ± 0.8 IU/μg protein) postoperative hour compared with pre-ECC values (4.9 ± 0.5 IU/μg protein). A deep thrombocytopenia was found during ECC and until the 24th postoperative hour. A drop of leukocyte counts was found during ECC followed by an increase after ECC weaning. While no correlation was found between M-CSF concentrations and the leukocyte counts, M-CSF values were positively correlated with platelet counts only before and during ECC. Thus, M-CSF is not implicated in the thrombocytopenia and the leukopenia generated during CPB with ECC. However the elevated levels of M-CSFa few hours after the end of ECC might play a role in the inflammatory process often observed after CPB.http://dx.doi.org/10.1155/S0962935196000518 |
| spellingShingle | Y. Denizot P. Fixe E. Cornu N. Nathan Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation Mediators of Inflammation |
| title | Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation |
| title_full | Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation |
| title_fullStr | Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation |
| title_full_unstemmed | Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation |
| title_short | Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation |
| title_sort | plasma macrophage colony stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation |
| url | http://dx.doi.org/10.1155/S0962935196000518 |
| work_keys_str_mv | AT ydenizot plasmamacrophagecolonystimulatingfactorlevelsduringcardiopulmonarybypasswithextracorporealcirculation AT pfixe plasmamacrophagecolonystimulatingfactorlevelsduringcardiopulmonarybypasswithextracorporealcirculation AT ecornu plasmamacrophagecolonystimulatingfactorlevelsduringcardiopulmonarybypasswithextracorporealcirculation AT nnathan plasmamacrophagecolonystimulatingfactorlevelsduringcardiopulmonarybypasswithextracorporealcirculation |