The impact of absorbable hemostatic agents on wound healing in an experimental penile fracture rat model
Abstract Objective This study aimed to evaluate the effects of two absorbable hemostatic agents, oxidized regenerated cellulose (ORC) and gelatin sponge, on wound healing in a rat model of penile fracture. Materials and methods A total of 32 Wistar albino rats were divided into four groups: Control...
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2025-01-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-025-01697-8 |
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| author | Mehmet Ezer Engin Doğantekin Muzaffer Çaydere Aykut Koç Çağrı Öktem Sema Hücümenoğlu |
| author_facet | Mehmet Ezer Engin Doğantekin Muzaffer Çaydere Aykut Koç Çağrı Öktem Sema Hücümenoğlu |
| author_sort | Mehmet Ezer |
| collection | DOAJ |
| description | Abstract Objective This study aimed to evaluate the effects of two absorbable hemostatic agents, oxidized regenerated cellulose (ORC) and gelatin sponge, on wound healing in a rat model of penile fracture. Materials and methods A total of 32 Wistar albino rats were divided into four groups: Control (C), Primary Suturing (PS), ORC, and Gelatin Sponge (GS). A penile fracture model was created in all rats, and wound healing was assessed histopathologically after two weeks. Key parameters assessed included primary healing, fibrosis, inflammation, and cavernous tissue healing. Results The ORC group showed significantly higher primary healing rates (100%) compared to the other groups (p < 0.01). Fibrosis was more common in the GS group (87.5%), whereas no fibrosis was observed in the ORC group (p < 0.01). In terms of cavernous tissue healing, the group treated with the ORC absorbable hemostatic agent demonstrated significantly higher healing rates compared to the control group (p = 0.000). No significant differences were observed between groups regarding inflammation. Conclusion ORC absorbable hemostatic agents significantly promote primary wound healing and reduce fibrosis in an experimental penile fracture model, whereas the gelatin sponge was associated with increased fibrosis and did not improve healing. These findings suggest that ORC may have potential clinical applications in penile fracture repair. Further clinical studies are necessary to validate these results. |
| format | Article |
| id | doaj-art-52ab9837fb21494982bf9f1d6fd095d7 |
| institution | Kabale University |
| issn | 1471-2490 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj-art-52ab9837fb21494982bf9f1d6fd095d72025-01-26T12:54:10ZengBMCBMC Urology1471-24902025-01-012511610.1186/s12894-025-01697-8The impact of absorbable hemostatic agents on wound healing in an experimental penile fracture rat modelMehmet Ezer0Engin Doğantekin1Muzaffer Çaydere2Aykut Koç3Çağrı Öktem4Sema Hücümenoğlu5Department of Urology, Kafkas University Medical SchoolDepartment of Urology, Antalya Training and Research HospitalDepartment of Pathology, Ankara Training and Research HospitalDepartment of Urology, Siirt Training and Research HospitalDepartment of Urology, Ankara Training and Research HospitalDepartment of Pathology, Ankara Training and Research HospitalAbstract Objective This study aimed to evaluate the effects of two absorbable hemostatic agents, oxidized regenerated cellulose (ORC) and gelatin sponge, on wound healing in a rat model of penile fracture. Materials and methods A total of 32 Wistar albino rats were divided into four groups: Control (C), Primary Suturing (PS), ORC, and Gelatin Sponge (GS). A penile fracture model was created in all rats, and wound healing was assessed histopathologically after two weeks. Key parameters assessed included primary healing, fibrosis, inflammation, and cavernous tissue healing. Results The ORC group showed significantly higher primary healing rates (100%) compared to the other groups (p < 0.01). Fibrosis was more common in the GS group (87.5%), whereas no fibrosis was observed in the ORC group (p < 0.01). In terms of cavernous tissue healing, the group treated with the ORC absorbable hemostatic agent demonstrated significantly higher healing rates compared to the control group (p = 0.000). No significant differences were observed between groups regarding inflammation. Conclusion ORC absorbable hemostatic agents significantly promote primary wound healing and reduce fibrosis in an experimental penile fracture model, whereas the gelatin sponge was associated with increased fibrosis and did not improve healing. These findings suggest that ORC may have potential clinical applications in penile fracture repair. Further clinical studies are necessary to validate these results.https://doi.org/10.1186/s12894-025-01697-8Penil fractureOxidized regenerated cellulose absorbable hemostatAbsorbable hemostatic gelatin spongeSurgicelSpongostan |
| spellingShingle | Mehmet Ezer Engin Doğantekin Muzaffer Çaydere Aykut Koç Çağrı Öktem Sema Hücümenoğlu The impact of absorbable hemostatic agents on wound healing in an experimental penile fracture rat model BMC Urology Penil fracture Oxidized regenerated cellulose absorbable hemostat Absorbable hemostatic gelatin sponge Surgicel Spongostan |
| title | The impact of absorbable hemostatic agents on wound healing in an experimental penile fracture rat model |
| title_full | The impact of absorbable hemostatic agents on wound healing in an experimental penile fracture rat model |
| title_fullStr | The impact of absorbable hemostatic agents on wound healing in an experimental penile fracture rat model |
| title_full_unstemmed | The impact of absorbable hemostatic agents on wound healing in an experimental penile fracture rat model |
| title_short | The impact of absorbable hemostatic agents on wound healing in an experimental penile fracture rat model |
| title_sort | impact of absorbable hemostatic agents on wound healing in an experimental penile fracture rat model |
| topic | Penil fracture Oxidized regenerated cellulose absorbable hemostat Absorbable hemostatic gelatin sponge Surgicel Spongostan |
| url | https://doi.org/10.1186/s12894-025-01697-8 |
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