The Need for Inducing Tolerance in Vascularized Composite Allotransplantation
Successful hand and face transplantation in the last decade has firmly established the field of vascularized composite allotransplantation (VCA). The experience in VCA has thus far been very similar to solid organ transplantation in terms of the morbidity associated with long-term immunosuppression....
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/438078 |
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| author | Kadiyala V. Ravindra Hong Xu Larry D. Bozulic David D. Song Suzanne T. Ildstad |
| author_facet | Kadiyala V. Ravindra Hong Xu Larry D. Bozulic David D. Song Suzanne T. Ildstad |
| author_sort | Kadiyala V. Ravindra |
| collection | DOAJ |
| description | Successful hand and face transplantation in the last decade has firmly established the field of vascularized composite allotransplantation (VCA). The experience in VCA has thus far been very similar to solid organ transplantation in terms of the morbidity associated with long-term immunosuppression. The unique immunological features of VCA such as split tolerance and resistance to chronic rejection are being investigated. Simultaneously there has been laboratory work studying tolerogenic protocols in animal VCA models. In order to optimize VCA outcomes, translational studies are needed to develop less toxic immunosuppression and possibly achieve donor-specific tolerance. This article reviews the immunology, animal models, mixed chimerism & tolerance induction in VCA and the direction of future research to enable better understanding and wider application of VCA. |
| format | Article |
| id | doaj-art-528ed9632ec84a71b569835aacb49cfc |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-528ed9632ec84a71b569835aacb49cfc2025-02-03T05:45:15ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/438078438078The Need for Inducing Tolerance in Vascularized Composite AllotransplantationKadiyala V. Ravindra0Hong Xu1Larry D. Bozulic2David D. Song3Suzanne T. Ildstad4Department of Surgery, Duke University Medical Center (DUMC) 3512, Durham, NC 27710, USAInstitute for Cellular Therapeutics and Jewish Hospital, University of Louisville, 570 South Preston Street, Suite 404, Louisville, KY 40202-1760, USAInstitute for Cellular Therapeutics and Jewish Hospital, University of Louisville, 570 South Preston Street, Suite 404, Louisville, KY 40202-1760, USAInstitute for Cellular Therapeutics and Jewish Hospital, University of Louisville, 570 South Preston Street, Suite 404, Louisville, KY 40202-1760, USAInstitute for Cellular Therapeutics and Jewish Hospital, University of Louisville, 570 South Preston Street, Suite 404, Louisville, KY 40202-1760, USASuccessful hand and face transplantation in the last decade has firmly established the field of vascularized composite allotransplantation (VCA). The experience in VCA has thus far been very similar to solid organ transplantation in terms of the morbidity associated with long-term immunosuppression. The unique immunological features of VCA such as split tolerance and resistance to chronic rejection are being investigated. Simultaneously there has been laboratory work studying tolerogenic protocols in animal VCA models. In order to optimize VCA outcomes, translational studies are needed to develop less toxic immunosuppression and possibly achieve donor-specific tolerance. This article reviews the immunology, animal models, mixed chimerism & tolerance induction in VCA and the direction of future research to enable better understanding and wider application of VCA.http://dx.doi.org/10.1155/2012/438078 |
| spellingShingle | Kadiyala V. Ravindra Hong Xu Larry D. Bozulic David D. Song Suzanne T. Ildstad The Need for Inducing Tolerance in Vascularized Composite Allotransplantation Clinical and Developmental Immunology |
| title | The Need for Inducing Tolerance in Vascularized Composite Allotransplantation |
| title_full | The Need for Inducing Tolerance in Vascularized Composite Allotransplantation |
| title_fullStr | The Need for Inducing Tolerance in Vascularized Composite Allotransplantation |
| title_full_unstemmed | The Need for Inducing Tolerance in Vascularized Composite Allotransplantation |
| title_short | The Need for Inducing Tolerance in Vascularized Composite Allotransplantation |
| title_sort | need for inducing tolerance in vascularized composite allotransplantation |
| url | http://dx.doi.org/10.1155/2012/438078 |
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