Association Study between Novel CYP26 Polymorphisms and the Risk of Betel Quid-Related Malignant Oral Disorders
BQ chewing may produce significant amounts of reactive oxygen species (ROS), resulting in oral mucosa damage, and ROS may be metabolized by CYP26 families. Because the CYP26 polymorphisms associated with malignant oral disorders are not well known, we conducted an association study on the associatio...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/160185 |
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| author | Shyh-Jong Wu Yun-Ju Chen Tien-Yu Shieh Chun-Ming Chen Yen-Yun Wang Kun-Tsung Lee Yueh-Ming Lin Pei-Hsuan Chien Ping-Ho Chen |
| author_facet | Shyh-Jong Wu Yun-Ju Chen Tien-Yu Shieh Chun-Ming Chen Yen-Yun Wang Kun-Tsung Lee Yueh-Ming Lin Pei-Hsuan Chien Ping-Ho Chen |
| author_sort | Shyh-Jong Wu |
| collection | DOAJ |
| description | BQ chewing may produce significant amounts of reactive oxygen species (ROS), resulting in oral mucosa damage, and ROS may be metabolized by CYP26 families. Because the CYP26 polymorphisms associated with malignant oral disorders are not well known, we conducted an association study on the associations between the single nucleotide polymorphisms (SNP) of CYP26 families and the risks of malignant oral disorders. BQ chewers with the CYP26A1 rs4411227 C/C+C/G genotype and C allele showed an increased risk of oral and pharyngeal cancer (adjusted odds ratio (aOR) = 2.30 and 1.93, respectively). The CYP26B1 rs3768647 G allele may be associated with oral and pharyngeal cancer (aOR = 3.12) and OPMDs (aOR = 2.23). Subjects with the rs9309462 CT genotype and C allele had an increased risk of oral and pharyngeal cancer (aOR = 9.24 and 8.86, respectively) and OPMDs (aOR = 8.17 and 7.87, respectively). The analysis of joint effects between the CYP26A1 rs4411227 and CYP26B1 rs3768647/rs9309462 polymorphisms revealed statistical significance (aOR = 29.91 and 10.03, respectively). Additionally, we observed a significant mRNA expression of CY26A1 and CYP26B1 in cancerous tissues compared with adjacent noncancerous tissues. Our findings suggest that novel CYP26 polymorphisms are associated with an increased risk of malignant oral disorders, particularly among BQ chewers. |
| format | Article |
| id | doaj-art-526b3ad97960459ba46a270f0d93fae3 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-526b3ad97960459ba46a270f0d93fae32025-02-03T01:24:23ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/160185160185Association Study between Novel CYP26 Polymorphisms and the Risk of Betel Quid-Related Malignant Oral DisordersShyh-Jong Wu0Yun-Ju Chen1Tien-Yu Shieh2Chun-Ming Chen3Yen-Yun Wang4Kun-Tsung Lee5Yueh-Ming Lin6Pei-Hsuan Chien7Ping-Ho Chen8Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 80708, TaiwanDepartment of Biological Science & Technology, I-Shou University, No. 1, Section 1, Syuecheng Road, Kaohsiung 84001, TaiwanSchool of Oral Hygiene, Taipei Medical University, No. 250, Wuxing Street, Taipei 11031, TaiwanSchool of Dentistry, College of Dental Medicine, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 807, TaiwanDepartment of Clinical Research, Kaohsiung Medical University Hospital, No. 100, Shih-Chuan 1st Road, Kaohsiung 80708, TaiwanDepartment of Oral Hygiene, College of Dental Medicine, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 80708, TaiwanDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No. 123, Dapi Road, Kaohsiung 83301, TaiwanDepartment of Medical Research, E-Da Hospital, No. 1, Yida Road, Kaohsiung 82445, TaiwanSchool of Dentistry, College of Dental Medicine, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 807, TaiwanBQ chewing may produce significant amounts of reactive oxygen species (ROS), resulting in oral mucosa damage, and ROS may be metabolized by CYP26 families. Because the CYP26 polymorphisms associated with malignant oral disorders are not well known, we conducted an association study on the associations between the single nucleotide polymorphisms (SNP) of CYP26 families and the risks of malignant oral disorders. BQ chewers with the CYP26A1 rs4411227 C/C+C/G genotype and C allele showed an increased risk of oral and pharyngeal cancer (adjusted odds ratio (aOR) = 2.30 and 1.93, respectively). The CYP26B1 rs3768647 G allele may be associated with oral and pharyngeal cancer (aOR = 3.12) and OPMDs (aOR = 2.23). Subjects with the rs9309462 CT genotype and C allele had an increased risk of oral and pharyngeal cancer (aOR = 9.24 and 8.86, respectively) and OPMDs (aOR = 8.17 and 7.87, respectively). The analysis of joint effects between the CYP26A1 rs4411227 and CYP26B1 rs3768647/rs9309462 polymorphisms revealed statistical significance (aOR = 29.91 and 10.03, respectively). Additionally, we observed a significant mRNA expression of CY26A1 and CYP26B1 in cancerous tissues compared with adjacent noncancerous tissues. Our findings suggest that novel CYP26 polymorphisms are associated with an increased risk of malignant oral disorders, particularly among BQ chewers.http://dx.doi.org/10.1155/2015/160185 |
| spellingShingle | Shyh-Jong Wu Yun-Ju Chen Tien-Yu Shieh Chun-Ming Chen Yen-Yun Wang Kun-Tsung Lee Yueh-Ming Lin Pei-Hsuan Chien Ping-Ho Chen Association Study between Novel CYP26 Polymorphisms and the Risk of Betel Quid-Related Malignant Oral Disorders The Scientific World Journal |
| title | Association Study between Novel CYP26 Polymorphisms and the Risk of Betel Quid-Related Malignant Oral Disorders |
| title_full | Association Study between Novel CYP26 Polymorphisms and the Risk of Betel Quid-Related Malignant Oral Disorders |
| title_fullStr | Association Study between Novel CYP26 Polymorphisms and the Risk of Betel Quid-Related Malignant Oral Disorders |
| title_full_unstemmed | Association Study between Novel CYP26 Polymorphisms and the Risk of Betel Quid-Related Malignant Oral Disorders |
| title_short | Association Study between Novel CYP26 Polymorphisms and the Risk of Betel Quid-Related Malignant Oral Disorders |
| title_sort | association study between novel cyp26 polymorphisms and the risk of betel quid related malignant oral disorders |
| url | http://dx.doi.org/10.1155/2015/160185 |
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