Probiotics Reduce Postoperative Infections in Patients Undergoing Colorectal Surgery: A Systematic Review and Meta-Analysis
Background. We performed this meta-analysis to investigate the efficacy of probiotics on prevention of infection-related complications following colorectal resection. Method. PubMed, EMBASE, Cochrane Library, and the Web of Science were searched up to January 2016. According to the results, only ran...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/6029075 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545575378092032 |
|---|---|
| author | Peng Cheng Liu Yu Ke Yan Yu Jing Ma Xiang Wen Wang Jie Geng Man Cai Wang Feng Xian Wei Ya Wu Zhang Xiao Dong Xu You Cheng Zhang |
| author_facet | Peng Cheng Liu Yu Ke Yan Yu Jing Ma Xiang Wen Wang Jie Geng Man Cai Wang Feng Xian Wei Ya Wu Zhang Xiao Dong Xu You Cheng Zhang |
| author_sort | Peng Cheng Liu |
| collection | DOAJ |
| description | Background. We performed this meta-analysis to investigate the efficacy of probiotics on prevention of infection-related complications following colorectal resection. Method. PubMed, EMBASE, Cochrane Library, and the Web of Science were searched up to January 2016. According to the results, only randomized controlled trials that compared the efficacy of probiotics on patients with colorectal resection were included for meta-analysis. Results. Nine studies including a total of 1146 patients met the criteria (556 received multistrain probiotic bacteria, 590 with non-multistrain probiotic bacteria). The combination of multistrain probiotics was beneficial in the reduction of total infections (OR = 0.30, 95%CI: 0.15–0.61, p=0.0009), including surgical site infections (SSI) (OR = 0.48, 95%CI: 0.25–0.89, p=0.02) and nonsurgical site infections (NSSI) (OR = 0.36, 95%CI: 0.23–0.56, p<0.00001). However, there was no significant reduction in total infections (OR = 0.74, 95%CI: 0.50–1.09, p=0.13) or SSI (OR = 0.77, 95%CI: 0.52–1.12, p=0.17) with the application of non-multistrains of probiotics. Conclusion. Combinations of multistrain probiotic bacteria showed promise in preventing the incidence of infections following colorectal surgery. However, the efficacy of one or two strains of probiotics remains undetermined. |
| format | Article |
| id | doaj-art-52611c193bba4e8e97d880dbfba1f947 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-52611c193bba4e8e97d880dbfba1f9472025-02-03T07:25:17ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/60290756029075Probiotics Reduce Postoperative Infections in Patients Undergoing Colorectal Surgery: A Systematic Review and Meta-AnalysisPeng Cheng Liu0Yu Ke Yan1Yu Jing Ma2Xiang Wen Wang3Jie Geng4Man Cai Wang5Feng Xian Wei6Ya Wu Zhang7Xiao Dong Xu8You Cheng Zhang9Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaBackground. We performed this meta-analysis to investigate the efficacy of probiotics on prevention of infection-related complications following colorectal resection. Method. PubMed, EMBASE, Cochrane Library, and the Web of Science were searched up to January 2016. According to the results, only randomized controlled trials that compared the efficacy of probiotics on patients with colorectal resection were included for meta-analysis. Results. Nine studies including a total of 1146 patients met the criteria (556 received multistrain probiotic bacteria, 590 with non-multistrain probiotic bacteria). The combination of multistrain probiotics was beneficial in the reduction of total infections (OR = 0.30, 95%CI: 0.15–0.61, p=0.0009), including surgical site infections (SSI) (OR = 0.48, 95%CI: 0.25–0.89, p=0.02) and nonsurgical site infections (NSSI) (OR = 0.36, 95%CI: 0.23–0.56, p<0.00001). However, there was no significant reduction in total infections (OR = 0.74, 95%CI: 0.50–1.09, p=0.13) or SSI (OR = 0.77, 95%CI: 0.52–1.12, p=0.17) with the application of non-multistrains of probiotics. Conclusion. Combinations of multistrain probiotic bacteria showed promise in preventing the incidence of infections following colorectal surgery. However, the efficacy of one or two strains of probiotics remains undetermined.http://dx.doi.org/10.1155/2017/6029075 |
| spellingShingle | Peng Cheng Liu Yu Ke Yan Yu Jing Ma Xiang Wen Wang Jie Geng Man Cai Wang Feng Xian Wei Ya Wu Zhang Xiao Dong Xu You Cheng Zhang Probiotics Reduce Postoperative Infections in Patients Undergoing Colorectal Surgery: A Systematic Review and Meta-Analysis Gastroenterology Research and Practice |
| title | Probiotics Reduce Postoperative Infections in Patients Undergoing Colorectal Surgery: A Systematic Review and Meta-Analysis |
| title_full | Probiotics Reduce Postoperative Infections in Patients Undergoing Colorectal Surgery: A Systematic Review and Meta-Analysis |
| title_fullStr | Probiotics Reduce Postoperative Infections in Patients Undergoing Colorectal Surgery: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Probiotics Reduce Postoperative Infections in Patients Undergoing Colorectal Surgery: A Systematic Review and Meta-Analysis |
| title_short | Probiotics Reduce Postoperative Infections in Patients Undergoing Colorectal Surgery: A Systematic Review and Meta-Analysis |
| title_sort | probiotics reduce postoperative infections in patients undergoing colorectal surgery a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2017/6029075 |
| work_keys_str_mv | AT pengchengliu probioticsreducepostoperativeinfectionsinpatientsundergoingcolorectalsurgeryasystematicreviewandmetaanalysis AT yukeyan probioticsreducepostoperativeinfectionsinpatientsundergoingcolorectalsurgeryasystematicreviewandmetaanalysis AT yujingma probioticsreducepostoperativeinfectionsinpatientsundergoingcolorectalsurgeryasystematicreviewandmetaanalysis AT xiangwenwang probioticsreducepostoperativeinfectionsinpatientsundergoingcolorectalsurgeryasystematicreviewandmetaanalysis AT jiegeng probioticsreducepostoperativeinfectionsinpatientsundergoingcolorectalsurgeryasystematicreviewandmetaanalysis AT mancaiwang probioticsreducepostoperativeinfectionsinpatientsundergoingcolorectalsurgeryasystematicreviewandmetaanalysis AT fengxianwei probioticsreducepostoperativeinfectionsinpatientsundergoingcolorectalsurgeryasystematicreviewandmetaanalysis AT yawuzhang probioticsreducepostoperativeinfectionsinpatientsundergoingcolorectalsurgeryasystematicreviewandmetaanalysis AT xiaodongxu probioticsreducepostoperativeinfectionsinpatientsundergoingcolorectalsurgeryasystematicreviewandmetaanalysis AT youchengzhang probioticsreducepostoperativeinfectionsinpatientsundergoingcolorectalsurgeryasystematicreviewandmetaanalysis |