Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature
Background. The malignant transformation of laryngeal papillomatosis (LP) into squamous cell carcinoma (SCC) can occur in up to 4% of LP cases. The low-risk HPV types 6 and 11 are those that are most commonly related to LP; however, high-risk HPV types may be present. The present study reviews the l...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2018/4362162 |
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| author | Vivian Narana Ribeiro El-Achkar Andressa Duarte Fabiano Pinto Saggioro Francisco Veríssimo De Mello Filho Jorge Esquiche León Alfredo Ribeiro-Silva Estela Kaminagakura |
| author_facet | Vivian Narana Ribeiro El-Achkar Andressa Duarte Fabiano Pinto Saggioro Francisco Veríssimo De Mello Filho Jorge Esquiche León Alfredo Ribeiro-Silva Estela Kaminagakura |
| author_sort | Vivian Narana Ribeiro El-Achkar |
| collection | DOAJ |
| description | Background. The malignant transformation of laryngeal papillomatosis (LP) into squamous cell carcinoma (SCC) can occur in up to 4% of LP cases. The low-risk HPV types 6 and 11 are those that are most commonly related to LP; however, high-risk HPV types may be present. The present study reviews the literature on cases of malignant transformation of LP in adults and reports a clinical case. Case Report. A 47-year-old male patient exhibiting hoarseness for 4 months presented an exophytic lesion in the right palatine tonsil and a digitiform-like lesion in the right vocal fold. The biopsy revealed a well-differentiated SCC in the vocal cord, which showed a transition zone with a squamous papillomatous lesion. By using the chromogenic in situ hybridization (CISH) test, both lesions showed a positive result for high-risk HPV types 16 and 18 and negative for low-risk HPV types 6 and 11. The final diagnosis was SCC arising from LP. The patient underwent surgical treatment. After 36 months of follow-up, no signs of recurrence were observed. Results. The literature review revealed 25 cases of malignant transformation into SCC of LP with adult onset. Of these, only 9 cases were assessed by CISH and/or PCR for HPV identification, of which 7 were positive. The current study focuses on the eighth case, suggesting the involvement of the high-risk HPV types in its pathogenesis. Conclusions. LP is considered a benign lesion with the potential for malignant transformation, which reinforces the need for its early diagnosis and the constant monitoring of patients with LP. |
| format | Article |
| id | doaj-art-525ae221b9fb40bda906953d26ab669f |
| institution | Kabale University |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-525ae221b9fb40bda906953d26ab669f2025-02-03T01:24:17ZengWileyCase Reports in Otolaryngology2090-67652090-67732018-01-01201810.1155/2018/43621624362162Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the LiteratureVivian Narana Ribeiro El-Achkar0Andressa Duarte1Fabiano Pinto Saggioro2Francisco Veríssimo De Mello Filho3Jorge Esquiche León4Alfredo Ribeiro-Silva5Estela Kaminagakura6DDS, PhD Student at Department of Bioscience and Oral Diagnosis, Science and Technology Institute, Universidade Estadual Paulista (UNESP), Sao Jose dos Campos, BrazilPhD Student at Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, BrazilPhD, Assistant Physician at Pathology Service of Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, BrazilMD, PhD, Associated Professor at Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilPhD, Professor at Department of Stomatology, Collective Health and Legal Dentistry, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, BrazilMD, PhD, Associated Professor at Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, BrazilDDs, PhD, Associated Professor at the Department of Bioscience and Oral Diagnosis, Science and Technology Institute, Universidade Estadual Paulista (UNESP), Sao José dos Campos, BrazilBackground. The malignant transformation of laryngeal papillomatosis (LP) into squamous cell carcinoma (SCC) can occur in up to 4% of LP cases. The low-risk HPV types 6 and 11 are those that are most commonly related to LP; however, high-risk HPV types may be present. The present study reviews the literature on cases of malignant transformation of LP in adults and reports a clinical case. Case Report. A 47-year-old male patient exhibiting hoarseness for 4 months presented an exophytic lesion in the right palatine tonsil and a digitiform-like lesion in the right vocal fold. The biopsy revealed a well-differentiated SCC in the vocal cord, which showed a transition zone with a squamous papillomatous lesion. By using the chromogenic in situ hybridization (CISH) test, both lesions showed a positive result for high-risk HPV types 16 and 18 and negative for low-risk HPV types 6 and 11. The final diagnosis was SCC arising from LP. The patient underwent surgical treatment. After 36 months of follow-up, no signs of recurrence were observed. Results. The literature review revealed 25 cases of malignant transformation into SCC of LP with adult onset. Of these, only 9 cases were assessed by CISH and/or PCR for HPV identification, of which 7 were positive. The current study focuses on the eighth case, suggesting the involvement of the high-risk HPV types in its pathogenesis. Conclusions. LP is considered a benign lesion with the potential for malignant transformation, which reinforces the need for its early diagnosis and the constant monitoring of patients with LP.http://dx.doi.org/10.1155/2018/4362162 |
| spellingShingle | Vivian Narana Ribeiro El-Achkar Andressa Duarte Fabiano Pinto Saggioro Francisco Veríssimo De Mello Filho Jorge Esquiche León Alfredo Ribeiro-Silva Estela Kaminagakura Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature Case Reports in Otolaryngology |
| title | Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature |
| title_full | Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature |
| title_fullStr | Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature |
| title_full_unstemmed | Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature |
| title_short | Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature |
| title_sort | squamous cell carcinoma originating from adult laryngeal papillomatosis case report and review of the literature |
| url | http://dx.doi.org/10.1155/2018/4362162 |
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