Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome
Sympathetic tone is well recognised as being implicit in cardiovascular control. It is less readily acknowledged that activation of the sympathetic nervous system is integral in energy homeostasis and can...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/341583 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559206488604672 |
|---|---|
| author | Alicia A. Thorp Markus P. Schlaich |
| author_facet | Alicia A. Thorp Markus P. Schlaich |
| author_sort | Alicia A. Thorp |
| collection | DOAJ |
| description | Sympathetic tone is
well recognised as being implicit in
cardiovascular control. It is less readily
acknowledged that activation of the sympathetic
nervous system is integral in energy homeostasis
and can exert profound metabolic effects.
Accumulating data from animal and human studies
suggest that central sympathetic overactivity
plays a pivotal role in the aetiology and
complications of several metabolic conditions
that can cluster to form the Metabolic Syndrome
(MetS). Given the known augmented risk for type
2 diabetes, cardiovascular disease, and premature
mortality associated with the MetS understanding
the complex pathways underlying the metabolic
derangements involved has become a priority.
Many factors have been proposed to contribute to
increased sympathetic nerve activity in
metabolic abnormalities including obesity,
impaired baroreflex sensitivity,
hyperinsulinemia, and elevated adipokine levels.
Furthermore there is mounting evidence to
suggest that chronic sympathetic overactivity can
potentiate two of the key metabolic alterations
of the MetS, central obesity and insulin
resistance. This review will discuss the
regulatory role of the sympathetic nervous
system in metabolic control and the proposed
pathophysiology linking sympathetic overactivity
to metabolic abnormalities. Pharmacological and
device-based approaches that target central
sympathetic drive will also be discussed as
possible therapeutic options to improve
metabolic control in at-risk patient
cohorts. |
| format | Article |
| id | doaj-art-52547f6c4555416cac5634e75bab8ec5 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-52547f6c4555416cac5634e75bab8ec52025-02-03T01:30:35ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/341583341583Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic SyndromeAlicia A. Thorp0Markus P. Schlaich1Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, AustraliaNeurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, AustraliaSympathetic tone is well recognised as being implicit in cardiovascular control. It is less readily acknowledged that activation of the sympathetic nervous system is integral in energy homeostasis and can exert profound metabolic effects. Accumulating data from animal and human studies suggest that central sympathetic overactivity plays a pivotal role in the aetiology and complications of several metabolic conditions that can cluster to form the Metabolic Syndrome (MetS). Given the known augmented risk for type 2 diabetes, cardiovascular disease, and premature mortality associated with the MetS understanding the complex pathways underlying the metabolic derangements involved has become a priority. Many factors have been proposed to contribute to increased sympathetic nerve activity in metabolic abnormalities including obesity, impaired baroreflex sensitivity, hyperinsulinemia, and elevated adipokine levels. Furthermore there is mounting evidence to suggest that chronic sympathetic overactivity can potentiate two of the key metabolic alterations of the MetS, central obesity and insulin resistance. This review will discuss the regulatory role of the sympathetic nervous system in metabolic control and the proposed pathophysiology linking sympathetic overactivity to metabolic abnormalities. Pharmacological and device-based approaches that target central sympathetic drive will also be discussed as possible therapeutic options to improve metabolic control in at-risk patient cohorts.http://dx.doi.org/10.1155/2015/341583 |
| spellingShingle | Alicia A. Thorp Markus P. Schlaich Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome Journal of Diabetes Research |
| title | Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome |
| title_full | Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome |
| title_fullStr | Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome |
| title_full_unstemmed | Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome |
| title_short | Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome |
| title_sort | relevance of sympathetic nervous system activation in obesity and metabolic syndrome |
| url | http://dx.doi.org/10.1155/2015/341583 |
| work_keys_str_mv | AT aliciaathorp relevanceofsympatheticnervoussystemactivationinobesityandmetabolicsyndrome AT markuspschlaich relevanceofsympatheticnervoussystemactivationinobesityandmetabolicsyndrome |