Unbinding of alpha chain of hemoglobin in sickle and normal structures

Unbinding of alpha chain of hemoglobin in sickle and normal structures

Sickle cell disease, a genetic disorder, is caused by a mutation of glutamic acid into valine in β chain of hemoglobin at the sixth residue, resulting in structural change of the entire hemoglobin molecule into a sickle shape. We investigated the atomic level interaction between the α chain (chain A...

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Bibliographic Details
Main Authors: Jhulan Powrel, Rajendra Prasad Koirala, Narayan Prasad Adhikari
Format: Article
Language:English
Published: IOP Publishing 2025-01-01
Series:Journal of Physics Communications
Subjects:
mutation
sickle hemoglobin
decoupling
genetic
contact area
Online Access:https://doi.org/10.1088/2399-6528/ada985
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