CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective
Cytokeratins belong to the family of intermediate filaments. They are expressed in a highly specific manner in epithelial cells where they play a crucial role in the integrity and mechanical stability of the cells. Several types of cytokeratins have been described in normal as well as neoplastic uro...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2020/4920236 |
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| author | Mohammed Akhtar Sameera Rashid Mohamed Ben Gashir Noheir Mostafa Taha Issam Al Bozom |
| author_facet | Mohammed Akhtar Sameera Rashid Mohamed Ben Gashir Noheir Mostafa Taha Issam Al Bozom |
| author_sort | Mohammed Akhtar |
| collection | DOAJ |
| description | Cytokeratins belong to the family of intermediate filaments. They are expressed in a highly specific manner in epithelial cells where they play a crucial role in the integrity and mechanical stability of the cells. Several types of cytokeratins have been described in normal as well as neoplastic urothelium. In the case of urothelial neoplasms expression of CK20 and CK5/6 has been shown in several studies to have diagnostic and prognostic implications. Thus, low-grade urothelial carcinoma manifests CK expression limited to the umbrella cells, while high-grade tumors usually have an expression in the entire thickness of the urothelium except for the basal layer. CK5/6 expression on the other hand is expressed in the basal cells in all low-grade and some high-grade urothelial carcinomas. Diffuse CK20 staining accompanied by loss of CK5/6-positive basal layer is usually associated with aggressive clinical behavior. Double staining of the slides for these cytokeratins may facilitate proper interpretation and correlation. |
| format | Article |
| id | doaj-art-5247e8cf15134f07bf938a99c1221212 |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-5247e8cf15134f07bf938a99c12212122025-02-03T06:43:30ZengWileyAdvances in Urology1687-63691687-63772020-01-01202010.1155/2020/49202364920236CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A PerspectiveMohammed Akhtar0Sameera Rashid1Mohamed Ben Gashir2Noheir Mostafa Taha3Issam Al Bozom4Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, QatarDepartment of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, QatarDepartment of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, QatarDepartment of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, QatarDepartment of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, QatarCytokeratins belong to the family of intermediate filaments. They are expressed in a highly specific manner in epithelial cells where they play a crucial role in the integrity and mechanical stability of the cells. Several types of cytokeratins have been described in normal as well as neoplastic urothelium. In the case of urothelial neoplasms expression of CK20 and CK5/6 has been shown in several studies to have diagnostic and prognostic implications. Thus, low-grade urothelial carcinoma manifests CK expression limited to the umbrella cells, while high-grade tumors usually have an expression in the entire thickness of the urothelium except for the basal layer. CK5/6 expression on the other hand is expressed in the basal cells in all low-grade and some high-grade urothelial carcinomas. Diffuse CK20 staining accompanied by loss of CK5/6-positive basal layer is usually associated with aggressive clinical behavior. Double staining of the slides for these cytokeratins may facilitate proper interpretation and correlation.http://dx.doi.org/10.1155/2020/4920236 |
| spellingShingle | Mohammed Akhtar Sameera Rashid Mohamed Ben Gashir Noheir Mostafa Taha Issam Al Bozom CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective Advances in Urology |
| title | CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective |
| title_full | CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective |
| title_fullStr | CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective |
| title_full_unstemmed | CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective |
| title_short | CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective |
| title_sort | ck20 and ck5 6 immunohistochemical staining of urothelial neoplasms a perspective |
| url | http://dx.doi.org/10.1155/2020/4920236 |
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