Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats
This study was designed to investigate the effect of prenatal exposure to synthetic sex steroid on sperm quantity and quality, relative testicular and epididymal weights, and reproductive hormones level in adult Wistar rats. Forty male Wistar rats were divided into two groups: a test group (n = 20)...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/1814867 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568496506011648 |
|---|---|
| author | Samy Ismail Ahmed Aamir Magzoub Mohammed Saeed Zayed Al-Ayed Gamal Ali Attia Basel A. Abdel-Wahab Masood M. Khateeb Asim M. Abdalla Heitham M. Mohammed Aymen N. Eldeen A. Elkareem Ali Gadkarim A. Salih |
| author_facet | Samy Ismail Ahmed Aamir Magzoub Mohammed Saeed Zayed Al-Ayed Gamal Ali Attia Basel A. Abdel-Wahab Masood M. Khateeb Asim M. Abdalla Heitham M. Mohammed Aymen N. Eldeen A. Elkareem Ali Gadkarim A. Salih |
| author_sort | Samy Ismail Ahmed |
| collection | DOAJ |
| description | This study was designed to investigate the effect of prenatal exposure to synthetic sex steroid on sperm quantity and quality, relative testicular and epididymal weights, and reproductive hormones level in adult Wistar rats. Forty male Wistar rats were divided into two groups: a test group (n = 20) that included mature rats that were born to dams exposed to gestational treatment with hydroxyprogesterone and a control group (n = 20) that included mature rats born to untreated dams. Compared to the control group, the test group showed a significant reduction in the sperm count, viability and motility, relative testicular and epididymal weights together with increased abnormal spermatozoa (p<0.001). The reproductive hormonal assay revealed significantly lower serum testosterone and higher levels of FSH and LH among the test groups compared to the control (p<0.05 for all). Prenatal exposure to synthetic progesterone negatively affected sperm production and function, relative testicular and epididymal weights, and reproductive hormone levels. |
| format | Article |
| id | doaj-art-52471b60aa41440dbd179ecbc9dbc125 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-52471b60aa41440dbd179ecbc9dbc1252025-02-03T00:58:57ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/18148671814867Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar RatsSamy Ismail Ahmed0Aamir Magzoub1Mohammed Saeed Zayed Al-Ayed2Gamal Ali Attia3Basel A. Abdel-Wahab4Masood M. Khateeb5Asim M. Abdalla6Heitham M. Mohammed7Aymen N. Eldeen A. Elkareem8Ali Gadkarim A. Salih9Department of Anatomy, College of Medicine, Najran University, Najran, Saudi ArabiaDepartment of Physiology, College of Medicine, Najran University, Najran, Saudi ArabiaDepartment of Paediatrics, College of Medicine, Najran University, Najran, Saudi ArabiaDepartment of Anatomy, College of Medicine, Assiut University, Assiut, EgyptDepartment of Pharmacology, College of Medicine, Assiut University, Assiut, EgyptDepartment of Pharmacology, College of Medicine, Najran University, Najran, Saudi ArabiaDepartment of Anatomy, College of Medicine, King Khalid University, Abha, Saudi ArabiaDepartment of Anatomy, College of Medicine, King Khalid University, Abha, Saudi ArabiaDepartment of Anatomy, College of Medicine, Najran University, Najran, Saudi ArabiaDepartment of Anatomy, College of Medicine, King Khalid University, Abha, Saudi ArabiaThis study was designed to investigate the effect of prenatal exposure to synthetic sex steroid on sperm quantity and quality, relative testicular and epididymal weights, and reproductive hormones level in adult Wistar rats. Forty male Wistar rats were divided into two groups: a test group (n = 20) that included mature rats that were born to dams exposed to gestational treatment with hydroxyprogesterone and a control group (n = 20) that included mature rats born to untreated dams. Compared to the control group, the test group showed a significant reduction in the sperm count, viability and motility, relative testicular and epididymal weights together with increased abnormal spermatozoa (p<0.001). The reproductive hormonal assay revealed significantly lower serum testosterone and higher levels of FSH and LH among the test groups compared to the control (p<0.05 for all). Prenatal exposure to synthetic progesterone negatively affected sperm production and function, relative testicular and epididymal weights, and reproductive hormone levels.http://dx.doi.org/10.1155/2020/1814867 |
| spellingShingle | Samy Ismail Ahmed Aamir Magzoub Mohammed Saeed Zayed Al-Ayed Gamal Ali Attia Basel A. Abdel-Wahab Masood M. Khateeb Asim M. Abdalla Heitham M. Mohammed Aymen N. Eldeen A. Elkareem Ali Gadkarim A. Salih Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats International Journal of Endocrinology |
| title | Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats |
| title_full | Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats |
| title_fullStr | Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats |
| title_full_unstemmed | Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats |
| title_short | Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats |
| title_sort | gestational exposure to synthetic steroid hormones impaired sperm quantity and quality in wistar rats |
| url | http://dx.doi.org/10.1155/2020/1814867 |
| work_keys_str_mv | AT samyismailahmed gestationalexposuretosyntheticsteroidhormonesimpairedspermquantityandqualityinwistarrats AT aamirmagzoub gestationalexposuretosyntheticsteroidhormonesimpairedspermquantityandqualityinwistarrats AT mohammedsaeedzayedalayed gestationalexposuretosyntheticsteroidhormonesimpairedspermquantityandqualityinwistarrats AT gamalaliattia gestationalexposuretosyntheticsteroidhormonesimpairedspermquantityandqualityinwistarrats AT baselaabdelwahab gestationalexposuretosyntheticsteroidhormonesimpairedspermquantityandqualityinwistarrats AT masoodmkhateeb gestationalexposuretosyntheticsteroidhormonesimpairedspermquantityandqualityinwistarrats AT asimmabdalla gestationalexposuretosyntheticsteroidhormonesimpairedspermquantityandqualityinwistarrats AT heithammmohammed gestationalexposuretosyntheticsteroidhormonesimpairedspermquantityandqualityinwistarrats AT aymenneldeenaelkareem gestationalexposuretosyntheticsteroidhormonesimpairedspermquantityandqualityinwistarrats AT aligadkarimasalih gestationalexposuretosyntheticsteroidhormonesimpairedspermquantityandqualityinwistarrats |