Growth Factors and Anticatabolic Substances for Prevention and Management of Intervertebral Disc Degeneration
Intervertebral disc (IVD) degeneration is frequent, appearing from the second decade of life and progressing with age. Conservative management often fails, and patients with IVD degeneration may need surgical intervention. Several treatment strategies have been proposed, although only surgical disce...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/897183 |
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| author | Umile Giuseppe Longo Stefano Petrillo Edoardo Franceschetti Nicola Maffulli Vincenzo Denaro |
| author_facet | Umile Giuseppe Longo Stefano Petrillo Edoardo Franceschetti Nicola Maffulli Vincenzo Denaro |
| author_sort | Umile Giuseppe Longo |
| collection | DOAJ |
| description | Intervertebral disc (IVD) degeneration is frequent, appearing from the second decade of life and progressing with age. Conservative management often fails, and patients with IVD degeneration may need surgical intervention. Several treatment strategies have been proposed, although only surgical discectomy and arthrodesis have been proved to be predictably effective. Biological strategies aim to prevent and manage IVD degeneration, improving the function and anabolic and reparative capabilities of the nucleus pulposus and annulus fibrosus cells and inhibiting matrix degradation. At present, clinical applications are still in their infancy. Further studies are required to clarify the role of growth factors and anticatabolic substances for prevention and management of intervertebral disc degeneration. |
| format | Article |
| id | doaj-art-523c3eb0db8c49bfb21b4ea7707029b2 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-523c3eb0db8c49bfb21b4ea7707029b22025-02-03T01:22:07ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/897183897183Growth Factors and Anticatabolic Substances for Prevention and Management of Intervertebral Disc DegenerationUmile Giuseppe Longo0Stefano Petrillo1Edoardo Franceschetti2Nicola Maffulli3Vincenzo Denaro4Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico, University of Rome, Via Álvaro del Portillo 200, 00128 Rome, ItalyDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico, University of Rome, Via Álvaro del Portillo 200, 00128 Rome, ItalyDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico, University of Rome, Via Álvaro del Portillo 200, 00128 Rome, ItalyCentre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London E1 4DG, UKDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico, University of Rome, Via Álvaro del Portillo 200, 00128 Rome, ItalyIntervertebral disc (IVD) degeneration is frequent, appearing from the second decade of life and progressing with age. Conservative management often fails, and patients with IVD degeneration may need surgical intervention. Several treatment strategies have been proposed, although only surgical discectomy and arthrodesis have been proved to be predictably effective. Biological strategies aim to prevent and manage IVD degeneration, improving the function and anabolic and reparative capabilities of the nucleus pulposus and annulus fibrosus cells and inhibiting matrix degradation. At present, clinical applications are still in their infancy. Further studies are required to clarify the role of growth factors and anticatabolic substances for prevention and management of intervertebral disc degeneration.http://dx.doi.org/10.1155/2012/897183 |
| spellingShingle | Umile Giuseppe Longo Stefano Petrillo Edoardo Franceschetti Nicola Maffulli Vincenzo Denaro Growth Factors and Anticatabolic Substances for Prevention and Management of Intervertebral Disc Degeneration Stem Cells International |
| title | Growth Factors and Anticatabolic Substances for Prevention and Management of Intervertebral Disc Degeneration |
| title_full | Growth Factors and Anticatabolic Substances for Prevention and Management of Intervertebral Disc Degeneration |
| title_fullStr | Growth Factors and Anticatabolic Substances for Prevention and Management of Intervertebral Disc Degeneration |
| title_full_unstemmed | Growth Factors and Anticatabolic Substances for Prevention and Management of Intervertebral Disc Degeneration |
| title_short | Growth Factors and Anticatabolic Substances for Prevention and Management of Intervertebral Disc Degeneration |
| title_sort | growth factors and anticatabolic substances for prevention and management of intervertebral disc degeneration |
| url | http://dx.doi.org/10.1155/2012/897183 |
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