Multifocal Pigmented Villonodular Synovitis in the Noonan Syndrome
Noonan-like/multiple giant cell lesion (NS/MGCL) is a rare condition overlapping with Noonan syndrome. Once thought to be a specific and separate entity, it is now suggested to be a variant of the Noonan syndrome spectrum. We report the case of an 8-year-old boy with a typical clinical picture of No...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Orthopedics |
| Online Access: | http://dx.doi.org/10.1155/2018/7698052 |
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| author | Othmane Miri Nicolas Bonnet Philippe Lysy Naima Loucheur René Gayito Pierre Louis Docquier |
| author_facet | Othmane Miri Nicolas Bonnet Philippe Lysy Naima Loucheur René Gayito Pierre Louis Docquier |
| author_sort | Othmane Miri |
| collection | DOAJ |
| description | Noonan-like/multiple giant cell lesion (NS/MGCL) is a rare condition overlapping with Noonan syndrome. Once thought to be a specific and separate entity, it is now suggested to be a variant of the Noonan syndrome spectrum. We report the case of an 8-year-old boy with a typical clinical picture of Noonan syndrome with a de novo germline mutation of PTPN11 (c.854 T>C). During his follow-up, the patient developed multifocal pigmented villonodular synovitis which first affected the left knee and shortly after both elbows. |
| format | Article |
| id | doaj-art-52350ef3ec5a426384f6f30cd01656d8 |
| institution | Kabale University |
| issn | 2090-6749 2090-6757 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Orthopedics |
| spelling | doaj-art-52350ef3ec5a426384f6f30cd01656d82025-02-03T01:09:40ZengWileyCase Reports in Orthopedics2090-67492090-67572018-01-01201810.1155/2018/76980527698052Multifocal Pigmented Villonodular Synovitis in the Noonan SyndromeOthmane Miri0Nicolas Bonnet1Philippe Lysy2Naima Loucheur3René Gayito4Pierre Louis Docquier5Cliniques Universitaires Saint-Luc, Service d’Orthopédie et de Traumatologie de l’Appareil Locomoteur, Avenue Hippocrate 10, B-1200 Brussels, BelgiumCliniques Universitaires Saint-Luc, Service d’Endocrinologie Pédiatrique, Avenue Hippocrate 10, B-1200 Brussels, BelgiumCliniques Universitaires Saint-Luc, Service d’Endocrinologie Pédiatrique, Avenue Hippocrate 10, B-1200 Brussels, BelgiumCliniques Universitaires Saint-Luc, Service d’Orthopédie et de Traumatologie de l’Appareil Locomoteur, Avenue Hippocrate 10, B-1200 Brussels, BelgiumCliniques Universitaires Saint-Luc, Service d’Orthopédie et de Traumatologie de l’Appareil Locomoteur, Avenue Hippocrate 10, B-1200 Brussels, BelgiumCliniques Universitaires Saint-Luc, Service d’Orthopédie et de Traumatologie de l’Appareil Locomoteur, Avenue Hippocrate 10, B-1200 Brussels, BelgiumNoonan-like/multiple giant cell lesion (NS/MGCL) is a rare condition overlapping with Noonan syndrome. Once thought to be a specific and separate entity, it is now suggested to be a variant of the Noonan syndrome spectrum. We report the case of an 8-year-old boy with a typical clinical picture of Noonan syndrome with a de novo germline mutation of PTPN11 (c.854 T>C). During his follow-up, the patient developed multifocal pigmented villonodular synovitis which first affected the left knee and shortly after both elbows.http://dx.doi.org/10.1155/2018/7698052 |
| spellingShingle | Othmane Miri Nicolas Bonnet Philippe Lysy Naima Loucheur René Gayito Pierre Louis Docquier Multifocal Pigmented Villonodular Synovitis in the Noonan Syndrome Case Reports in Orthopedics |
| title | Multifocal Pigmented Villonodular Synovitis in the Noonan Syndrome |
| title_full | Multifocal Pigmented Villonodular Synovitis in the Noonan Syndrome |
| title_fullStr | Multifocal Pigmented Villonodular Synovitis in the Noonan Syndrome |
| title_full_unstemmed | Multifocal Pigmented Villonodular Synovitis in the Noonan Syndrome |
| title_short | Multifocal Pigmented Villonodular Synovitis in the Noonan Syndrome |
| title_sort | multifocal pigmented villonodular synovitis in the noonan syndrome |
| url | http://dx.doi.org/10.1155/2018/7698052 |
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