Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy
Aim. Investigation of the possibility of manufacturing biocompatible polymer particles which have the required properties for pulmonary delivery via inhalation and simultaneously act as vehicles of nanotherapeutics. Methods. Nanostructures were obtained from biocompatible polysaccharides by successi...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2015/763020 |
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| _version_ | 1832552157606313984 |
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| author | Katarzyna Jabłczyńska Magdalena Janczewska Aleksandra Kulikowska Tomasz R. Sosnowski |
| author_facet | Katarzyna Jabłczyńska Magdalena Janczewska Aleksandra Kulikowska Tomasz R. Sosnowski |
| author_sort | Katarzyna Jabłczyńska |
| collection | DOAJ |
| description | Aim. Investigation of the possibility of manufacturing biocompatible polymer particles which have the required properties for pulmonary delivery via inhalation and simultaneously act as vehicles of nanotherapeutics. Methods. Nanostructures were obtained from biocompatible polysaccharides by successive oxidation and reactive coiling in the aqueous phase. The resultant nanosuspensions of PAD (polyaldehyde dextran) and DACMC (dialdehyde carbomethylcellulose) were used as precursors in spray drying production of powders at variable process conditions. The resultant dry microparticles were characterized by SEM observations, and their properties related to delivery by inhalation were determined by laser diffraction spectrometry following the dispersion in the commercial inhaler. Finally, the possibility of the reconstitution of nanosuspensions by powders rehydration was evaluated. Results. Synthesized nanoparticles had size of 120–170 nm. Microparticles after drying had size of 0.5–5 µm and different surface morphology. Aerosolized particles obtained from powder dispersion in the inhaler had the volumetric median diameter of ~2 and ~1 µm for PAD and DACMC, respectively. Hydration of powders led to restoring the nanosuspensions with the average particle size similar to the precursor. Conclusions. PAD and DACMC can be used to obtain nanostructures which, after processing, take a form suitable for effective delivery to the lungs via inhalation. |
| format | Article |
| id | doaj-art-523097baf827475ca24fbcd45f58c8bf |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-523097baf827475ca24fbcd45f58c8bf2025-02-03T05:59:20ZengWileyInternational Journal of Polymer Science1687-94221687-94302015-01-01201510.1155/2015/763020763020Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation TherapyKatarzyna Jabłczyńska0Magdalena Janczewska1Aleksandra Kulikowska2Tomasz R. Sosnowski3Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, 00-645 Warsaw, PolandFaculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, 00-645 Warsaw, PolandFaculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, 00-645 Warsaw, PolandFaculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, 00-645 Warsaw, PolandAim. Investigation of the possibility of manufacturing biocompatible polymer particles which have the required properties for pulmonary delivery via inhalation and simultaneously act as vehicles of nanotherapeutics. Methods. Nanostructures were obtained from biocompatible polysaccharides by successive oxidation and reactive coiling in the aqueous phase. The resultant nanosuspensions of PAD (polyaldehyde dextran) and DACMC (dialdehyde carbomethylcellulose) were used as precursors in spray drying production of powders at variable process conditions. The resultant dry microparticles were characterized by SEM observations, and their properties related to delivery by inhalation were determined by laser diffraction spectrometry following the dispersion in the commercial inhaler. Finally, the possibility of the reconstitution of nanosuspensions by powders rehydration was evaluated. Results. Synthesized nanoparticles had size of 120–170 nm. Microparticles after drying had size of 0.5–5 µm and different surface morphology. Aerosolized particles obtained from powder dispersion in the inhaler had the volumetric median diameter of ~2 and ~1 µm for PAD and DACMC, respectively. Hydration of powders led to restoring the nanosuspensions with the average particle size similar to the precursor. Conclusions. PAD and DACMC can be used to obtain nanostructures which, after processing, take a form suitable for effective delivery to the lungs via inhalation.http://dx.doi.org/10.1155/2015/763020 |
| spellingShingle | Katarzyna Jabłczyńska Magdalena Janczewska Aleksandra Kulikowska Tomasz R. Sosnowski Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy International Journal of Polymer Science |
| title | Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy |
| title_full | Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy |
| title_fullStr | Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy |
| title_full_unstemmed | Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy |
| title_short | Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy |
| title_sort | preparation and characterization of biocompatible polymer particles as potential nanocarriers for inhalation therapy |
| url | http://dx.doi.org/10.1155/2015/763020 |
| work_keys_str_mv | AT katarzynajabłczynska preparationandcharacterizationofbiocompatiblepolymerparticlesaspotentialnanocarriersforinhalationtherapy AT magdalenajanczewska preparationandcharacterizationofbiocompatiblepolymerparticlesaspotentialnanocarriersforinhalationtherapy AT aleksandrakulikowska preparationandcharacterizationofbiocompatiblepolymerparticlesaspotentialnanocarriersforinhalationtherapy AT tomaszrsosnowski preparationandcharacterizationofbiocompatiblepolymerparticlesaspotentialnanocarriersforinhalationtherapy |