Transposable Elements: No More 'Junk DNA'
Since the advent of whole-genome sequencing, transposable elements (TEs), just thought to be 'junk' DNA, have been noticed because of their numerous copies in various eukaryotic genomes. Many studies about TEs have been conducted to discover their functions in their host genomes. Based on...
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BioMed Central
2012-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-10-226.pdf |
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| author | Yun-Ji Kim Jungnam Lee Kyudong Han |
| author_facet | Yun-Ji Kim Jungnam Lee Kyudong Han |
| author_sort | Yun-Ji Kim |
| collection | DOAJ |
| description | Since the advent of whole-genome sequencing, transposable elements (TEs), just thought to be 'junk' DNA, have been noticed because of their numerous copies in various eukaryotic genomes. Many studies about TEs have been conducted to discover their functions in their host genomes. Based on the results of those studies, it has been generally accepted that they have a function to cause genomic and genetic variations. However, their infinite functions are not fully elucidated. Through various mechanisms, including de novo TE insertions, TE insertion-mediated deletions, and recombination events, they manipulate their host genomes. In this review, we focus on Alu, L1, human endogenous retrovirus, and short interspersed element/variable number of tandem repeats/Alu (SVA) elements and discuss how they have affected primate genomes, especially the human and chimpanzee genomes, since their divergence. |
| format | Article |
| id | doaj-art-522de61b80be44e8bef16d5ea5d1d48c |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2012-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-522de61b80be44e8bef16d5ea5d1d48c2025-02-02T00:34:23ZengBioMed CentralGenomics & Informatics1598-866X2234-07422012-12-0110422623310.5808/GI.2012.10.4.22620Transposable Elements: No More 'Junk DNA'Yun-Ji Kim0Jungnam Lee1Kyudong Han2Department of Nanobiomedical Science, WCU Research Center, Dankook University, Cheonan 330-714, Korea.Department of Nanobiomedical Science, WCU Research Center, Dankook University, Cheonan 330-714, Korea.Department of Nanobiomedical Science, WCU Research Center, Dankook University, Cheonan 330-714, Korea.Since the advent of whole-genome sequencing, transposable elements (TEs), just thought to be 'junk' DNA, have been noticed because of their numerous copies in various eukaryotic genomes. Many studies about TEs have been conducted to discover their functions in their host genomes. Based on the results of those studies, it has been generally accepted that they have a function to cause genomic and genetic variations. However, their infinite functions are not fully elucidated. Through various mechanisms, including de novo TE insertions, TE insertion-mediated deletions, and recombination events, they manipulate their host genomes. In this review, we focus on Alu, L1, human endogenous retrovirus, and short interspersed element/variable number of tandem repeats/Alu (SVA) elements and discuss how they have affected primate genomes, especially the human and chimpanzee genomes, since their divergence.http://genominfo.org/upload/pdf/gni-10-226.pdf elementsDNA transposable elementsendogenous retroviruseslong interspersed nucleotide elementsSVA |
| spellingShingle | Yun-Ji Kim Jungnam Lee Kyudong Han Transposable Elements: No More 'Junk DNA' Genomics & Informatics elements DNA transposable elements endogenous retroviruses long interspersed nucleotide elements SVA |
| title | Transposable Elements: No More 'Junk DNA' |
| title_full | Transposable Elements: No More 'Junk DNA' |
| title_fullStr | Transposable Elements: No More 'Junk DNA' |
| title_full_unstemmed | Transposable Elements: No More 'Junk DNA' |
| title_short | Transposable Elements: No More 'Junk DNA' |
| title_sort | transposable elements no more junk dna |
| topic | elements DNA transposable elements endogenous retroviruses long interspersed nucleotide elements SVA |
| url | http://genominfo.org/upload/pdf/gni-10-226.pdf |
| work_keys_str_mv | AT yunjikim transposableelementsnomorejunkdna AT jungnamlee transposableelementsnomorejunkdna AT kyudonghan transposableelementsnomorejunkdna |